“…To date, at least seven cases of crystallization granuloma by NIF, including the present case, have been documented (Table S1). The infused concentration of NIF was 2–4 mg/mL, which was higher than the recommended concentration of 1 mg/mL. In all cases, the skin manifestations included ulceration, subcutaneous nodules arranged like a string of pearls and the discharge of a whitish crystallized substance.…”