Crystallography and the development of therapeutic medicines

Baker, Edward N.

doi:10.1107/s2052252518002555

Cited by 3 publications

(2 citation statements)

References 12 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Producing crystalline mAbs is challenging, owing to the complexity of mAb HOS and the degree of mAb conformational heterogeneity. However, several complementing technologies have evolved in recent years to ascertain structure and interactions, including circular dichroism (CD), infrared (IR) and raman spectroscopy, cryogenic-electron microscopy, and nuclear magnetic resonance (NMR) spectroscopy [148,150,151,152,153,154,155,156,157]. Of the technologies available for HOS elucidation, 2D-NMR and X-Ray crystallography (followed by MS) provide the highest sensitivity and local specificity.…”

Section: Computational Approaches For Aggregation Prediction and Rmentioning

confidence: 99%

Current Advancements in Addressing Key Challenges of Therapeutic Antibody Design, Manufacture, and Formulation

et al. 2019

View full text Add to dashboard Cite

Therapeutic antibody technology heavily dominates the biologics market and continues to present as a significant industrial interest in developing novel and improved antibody treatment strategies. Many noteworthy advancements in the last decades have propelled the success of antibody development; however, there are still opportunities for improvement. In considering such interest to develop antibody therapies, this review summarizes the array of challenges and considerations faced in the design, manufacture, and formulation of therapeutic antibodies, such as stability, bioavailability and immunological engagement. We discuss the advancement of technologies that address these challenges, highlighting key antibody engineered formats that have been adapted. Furthermore, we examine the implication of novel formulation technologies such as nanocarrier delivery systems for the potential to formulate for pulmonary delivery. Finally, we comprehensively discuss developments in computational approaches for the strategic design of antibodies with modulated functions.

show abstract

Section: Computational Approaches For Aggregation Prediction and Rmentioning

confidence: 99%

Current Advancements in Addressing Key Challenges of Therapeutic Antibody Design, Manufacture, and Formulation

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Structural biology has fulfilled a history-changing mission in science at the interface of physics, chemistry, and biology when for over six decades it has maintained its leading role in providing the structural basis for our understanding of life [1][2][3][4]. Its results were always regarded as exceptionally solid, and created a gold standard in biological research, almost unattainable in many other areas of life sciences.…”

Section: Introductionmentioning

confidence: 99%

On the evolution of the quality of macromolecular models in the PDB

et al. 2020

View full text Add to dashboard Cite

Crystallographic models of biological macromolecules have been ranked using the quality criteria associated with them in the Protein Data Bank (PDB). The outcomes of this quality analysis have been correlated with time and with the journals that published papers based on those models. The results show that the overall quality of PDB structures has substantially improved over the last ten years, but this period of progress was preceded by several years of stagnation or even depression. Moreover, the study shows that the historically observed negative correlation between journal impact and the quality of structural models presented therein seems to disappear as time progresses.

show abstract

Detecting anomalies in X-ray diffraction images using convolutional neural networks

Czyzewski

Krawiec

Brzeziński

et al. 2021

Expert Systems with Applications

View full text Add to dashboard Cite

Crystallography and the development of therapeutic medicines

Abstract: Advances in crystallography and cryo-EM promise to further enhance the proud role crystallography has played in the development of new medicines.

Cited by 3 publications

References 12 publications

Current Advancements in Addressing Key Challenges of Therapeutic Antibody Design, Manufacture, and Formulation

Current Advancements in Addressing Key Challenges of Therapeutic Antibody Design, Manufacture, and Formulation

On the evolution of the quality of macromolecular models in the PDB

Detecting anomalies in X-ray diffraction images using convolutional neural networks

Contact Info

Product

Resources

About