Crystallography and Crystal Engineering

Rissanen, Kari

doi:10.1002/9783527644131.ch10

Cited by 2 publications

(1 citation statement)

References 34 publications

(58 reference statements)

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“…In the solid, crystal structure analysis reveals many intermolecular contacts, which indicate weak London dispersion forces. , Those even can stabilize unusual species . Here, such weak interactions are driving forces, for example, for a specific crystal packing.…”

Section: Introductionmentioning

confidence: 99%

Chasing Weak Forces: Hierarchically Assembled Helicates as a Probe for the Evaluation of the Energetics of Weak Interactions

et al. 2017

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London dispersion forces are the weakest interactions between molecules. Because of this, their influence on chemical processes is often low, but can definitely not be ignored and even becomes important in case of molecules with large contact surfaces. Hierarchically assembled dinuclear titanium(IV) helicates represent a rare example in which the direct observation of London dispersion forces is possible in solution even in the presence of strong cohesive solvent effects. Hereby, the dispersion forces do not unlimitedly support the formation of the dimeric complexes. Although they have some favorable enthalpic contribution to the dimerization of the monomeric complex units, large flexible substituents become conformationally restricted by the interactions leading to an entropic disadvantage. The dimeric helicates are entropically destabilized.

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Section: Introductionmentioning

confidence: 99%

Chasing Weak Forces: Hierarchically Assembled Helicates as a Probe for the Evaluation of the Energetics of Weak Interactions

et al. 2017

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Calix[n]arenes as Goldmines for the Development of Chemical Entities of Pharmaceutical Interest

Varejão

Fátima²,

Fernandes

2013

CPD

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Calix[n]arenes are macrocyclic cone-shaped compounds formed from phenolic units linked by methylene groups in the ortho position. Structural features make calix[n]arenes a versatile class of molecules that are of great interest, particularly in the pharmaceutical field. The cavity-like shape gives calix[n]arenes the ability to selectively encapsulate ions or neutral molecules, which can be used to generate carrier systems capable of increasing the solubility and diffusivity of chemical species. These resulting systems can function as deliverers of bioactive guest molecules. Host-guest molecular interactions act as the cornerstone that prompts the application of calix[n]arenes in the pharmaceutical field. Understanding their interactions in host-guest complexes is essential for the development and application of new therapeutics. In the present review, the most utilized analytical techniques for characterizing calix[n]arene inclusion complexes are discussed, and an overview of the ability of a variety of calix[n]arenes to work as host molecules for the development of chemical entities of pharmaceutical interest is also presented.

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Crystallography and Crystal Engineering

Cited by 2 publications

References 34 publications

Chasing Weak Forces: Hierarchically Assembled Helicates as a Probe for the Evaluation of the Energetics of Weak Interactions

Chasing Weak Forces: Hierarchically Assembled Helicates as a Probe for the Evaluation of the Energetics of Weak Interactions

Calix[n]arenes as Goldmines for the Development of Chemical Entities of Pharmaceutical Interest

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