Crystallographic snapshots of host–guest interactions in drugs@metal–organic frameworks: towards mimicking molecular recognition processes

Abstract

We report a novel highly crystalline MOF, featuring hydroxyl-decorated channels, capable of distinctly organizing guest organic molecules within its pores.

Isolated Fe(III)–O Sites Catalyze the Hydrogenation of Acetylene in Ethylene Flows under Front-End Industrial Conditions

“…[19][20][21][22][23] Indeed, MOFs are especially good for supporting metal cations, 23 complexes 24 or small clusters 19,25 anchoring them to the walls of their channels. As a result, MOFs can exhibit extremely high catalytic activities -often combined with size-selectivity related to such confined state-exceptional characterization of the guest active species -by means of single crystal X-ray diffraction- 26,27 and also improved reuse capabilities compared to metal catalysts in solution. 19 The preparation of MOFs has been, traditionally, connected with the use of direct self-assembly methods.…”

Toward Engineering Chiral Rodlike Metal–Organic Frameworks with Rare Topologies

“…This exponential growth has been underpinned, to some extent, on the thorough quest of rational design strategies to build/functionalize -in a controlled manner -MOFs with predetermined dimensionalities and topologies, [11][12][13] and the possibility to use X-ray crystallography to follow and rationalize the proposed synthetic methodology. [14][15][16] These have enable MOFs to find applications in such diverse fields as gas adsorption and separation, [17][18][19][20] catalysis, 21,22 molecular recognition processes, 23,24 drug delivery, 25,26 magnetism 27,28 and water remediation. [29][30][31] However, this has not been the case for MOFs constructed from one-dimensional (1D) rod-like Secondary Building Units (SBUs).…”

Efficient Capture of Organic Dyes and Crystallographic Snapshots by a Highly Crystalline Amino‐Acid‐Derived Metal–Organic Framework

“…The solvent contents were estimated by TGA (Figure S10 in the Supporting Information). The N 2 adsorption isotherms of 1 , PY@1 , AO@1 , BG@1 , and MB@1 at 77 K (Figure S11 in the Supporting Information) were used to calculate the BET surface areas of the host–guest systems, which vary in the range 47.8–491.4 m 2 g −1 , which is significantly lower than that observed for ancestor compound 1 (828 m 2 g −1 ) and indicates the expected decrease in the accessible void space due to the presence of the organic guest molecules. The largest reduction of accessible void space was observed for BG@1 , which has a very low BET surface area of 47.8 m 2 g −1 , which can be explained by the larger size of the BG molecules (Scheme S1 in the Supporting Information and Figures and ).…”

“…In this context, we take advantage of the well‐known crystallinity, flexibility, robustness, and resulting host–guest chemistry of oxamato‐based MOFs to evaluate the importance of the suitable functionalization of the channels of a MOF to achieve efficient water remediation. Therefore, we used a previously reported neutral 3D MOF, constructed with oxamato ligands derived from the natural amino acid l ‐serine, with formula {Ca II Cu II 6 [( S , S )‐serimox] 3 (OH) 2 (H 2 O)} ⋅ 39 H 2 O ( 1 ; serimox=bis[( S )‐serine]oxalyl diamide) . Compound 1 , which has channels functionalized with flexible serine (−CH 2 OH) residues, is capable of efficiently cleaning up contaminated aqueous solutions containing very low concentrations (10 ppm) of organic dyes such as Pyronin Y (PY), Auramine O (AO), Brilliant Green (BG), and Methylene Blue (MB) (Scheme S1 in the Supporting Information).…”