Crystallographic investigation of cetylpalmitate solid lipid nanoparticles

A novel approach to oral iron delivery using ferrous sulphate loaded solid lipid nanoparticles

“…Previous studies in SLN's have demonstrated that during formulation the lipid components undergo arrangements into lamellar lattice structures, and crystalline compounds are incorporated and stored within these layers (Lukowski et al 2000).Our DSC data therefore suggest that ferrous sulphate is successfully incorporated within the lipid matrix of the SLN's during the formulation process and is in agreement with the results of our iron incorporation efficiency experiments. …”

Differential scanning calorimetry studies on sunscreen loaded solid lipid nanoparticles prepared by the phase inversion temperature method

“…This last hypothesis could be supported by CP arrangement into a lamellar lattice structure in SLN. Lukowsky et al (2000) demonstrated, by crystallographic studies on SLN prepared using CP as solid lipid, that cetyl palmitate was arranged in a lamellar lattice structure and suggested that crystalline compounds could be stored between these layers. The crystalline nature of BMBM at room temperature could lead to its insertion between CP lamellar layers without any interaction with the solid lipid.…”

“…Wissing and Muller (2002b) reported that since SLN scattering ability depends strongly on the degree of crystallinity of their lipid matrix, SLN with a highly crystalline lipid matrix should be used to incorporate molecular sunscreens. Cetyl palmitate is one of the most widely used solid lipid for SLN preparation due to its safety and its crystal structure that leads to SLN in a crystalline form (Lukowsky et al, 2000;Wang et al, 2009). However, Xia et al (2007) pointed out that the use of cetyl palmitate as lipid matrix to obtain sunscreen loaded SLN did not provide SLN with good physico-chemical properties.…”

Rice Bran Oil

“…Cetyl palmitate is a type of wax of high interest due to its better in vitro degradation and lower in vivo toxicity as compared with other types of wax. 72 Different concentrations of SLNs prepared from γ-oryzanol and cetyl palmitate were evaluated. The particles were between 220-280 nanometers, and the entrapment efficiency of γ-oryzanol within SLNs varied from 15% to 66% using 9.5% and 8.5% (w/w) of cetyl palmitate.…”