Crystallizing ideas about Parkinson's disease

Cookson, Mark

doi:10.1073/pnas.1633722100

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…This protein shares more than 90% of homology with the human protein oncogene DJ1, which seems to be involved in the cellular oxidative stress response. 29 Of special interest are those proteins altered in untreated SHR and not modified by antihypertensive treatment, as calsarcin 1 with increased expression levels in all SHR groups. Calsarcin-1, specifically expressed in adult cardiac tissue, interacts and co-localizes with the Z-disk protein alpha-actinin, tethering calcineurin to the sarcomere of cardiac muscle.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Protein Profile of Established and Regressed Hypertension-Induced Left Ventricular Hypertrophy

et al. 2005

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Established left ventricular hypertrophy (LVH) showed a significant alteration in the cardiac protein profile compared with normal heart. The main finding of this work was to identify proteins differently expressed in hypertension-induced LVH and the fact that after regression of LVH (histologically determined), the proteome still maintains a number of expressed proteins characteristic of the hypertrophied heart. These unrecovered proteins play an essential role in the energy production pathway, in cellular stress defense and also in hypertrophy regulation.

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Section: Discussionmentioning

confidence: 99%

Comparison of the Protein Profile of Established and Regressed Hypertension-Induced Left Ventricular Hypertrophy

et al. 2005

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“…In addition, Parkin binds directly to the proteasome (via its Ubl domain), as well as to several other substrates, such as the septins CDCrel-1/2, expanded polyglutamine proteins responsible for PolyQ disease, cyclin E, and others (reviewed in Ref. 70,415).…”

Section: Pdmentioning

confidence: 99%

Role of Ubiquitylation in Cellular Membrane Transport

Staub

Rotin²

2006

Physiological Reviews

191

167

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Ubiquitylation of membrane proteins has gained considerable interest in recent years. It has been recognized as a signal that negatively regulates the cell surface expression of many plasma membrane proteins both in yeast and in mammalian cells. Moreover, it is also involved in endoplasmic reticulum-associated degradation of membrane proteins, and it acts as a sorting signal both in the secretory pathway and in endosomes, where it targets proteins into multivesicular bodies in the lumen of vacuoles/lysosomes. In this review we discuss the progress in understanding these processes, achieved during the past several years.

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“…The role of SUMOs is to control protein transfer between the cytoplasm and the nucleus. Normally, PARK7 is sumoylated at Lys130 by the E3-like enzyme PIAS [54]. Aspartyl protease cathepsin D (APCD) is also involved in protein degradation.…”

Section: Genetic Factors Affecting Parkinson's Disease and The Efficimentioning

confidence: 99%

Neurodegenerative Disorders: The Role of Genetic Factors in Their Origin and the Efficiency of Treatment

2005

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The review considers the main molecular physiological causes of neurodegenerative disorders. The genetic factors involved in Parkinson's and Alzheimer's diseases are conventionally divided into pharmacodynamic and pharmacokinetic. The former are analyzed at the levels of dopamine (DA) neurons and polymorphism of the D 1 , D 2 , and D 3 DA receptors. The role of polymorphisms of some proteins such as parkin (PARK1-PARK10) and α -synuclein in generation of Lewy bodies is described. The pharmacokinetic factors play a role in Parkinson's disease (PD) at the level of metabolism of DA, dioxyphenylalanine, and tyrosine and include polymorphisms of enzymes and proteins involved in the relevant metabolic reactions. The profile of DA metabolites may contribute to neurotoxicity and the development of PD. Prospects of drug therapy of PD and the risk of adverse drug effects such as mental disorders and dyskinesia are considered in terms of polymorphisms of enzymes and transport proteins.

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Crystallizing ideas about Parkinson's disease

Cited by 9 publications

References 25 publications

Comparison of the Protein Profile of Established and Regressed Hypertension-Induced Left Ventricular Hypertrophy

Comparison of the Protein Profile of Established and Regressed Hypertension-Induced Left Ventricular Hypertrophy

Role of Ubiquitylation in Cellular Membrane Transport

Neurodegenerative Disorders: The Role of Genetic Factors in Their Origin and the Efficiency of Treatment

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