Crystallization seeds favour crystallization only during initial growth

Allahyarov, Elshad; Sandomirski, Kirill; Egelhaaf, Stefan U.; Löwen, Hartmut

doi:10.1038/ncomms8110

Cited by 69 publications

(62 citation statements)

References 53 publications

(91 reference statements)

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“…Additionally, recent work by Allahyarov et al. provides evidence for a similar type of behavior with heterogeneous seeds which are present at the start of the crystallization process …”

Section: Resultsmentioning

confidence: 84%

The kinetics of homogeneous and two‐step nucleation during protein crystal growth from solution

Barlow¹,

Gregus

2019

Int J of Chemical Kinetics

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Many experimental reports for the kinetics of crystal nucleation and growth, from an isothermal solution, point to a sigmoidal‐like behavior for the process. Here we consider three different nucleation models from the literature and show that all lead to sigmoidal or sigmoidal‐like behavior for the kinetics of nucleation. A two‐step nucleation process is known to occur within certain supersaturated protein solutions, and it is demonstrated in this report how the sigmoidal law yields kinetic information for the two‐step and homogeneous nucleation modes. We propose here that two‐step solute‐rich associates form in the solution around seed nuclei that are already present at or near the point in time when the solution is prepared. Using this hypothesis, we are able to model the time‐dependent volume of the two‐step phase per unit volume of solution and show that this compares well with reported experimental data. A kinetic model is given for the proposed process, which leads to a sigmoidal rate law. Additionally, a relation between the initial and final nuclei densities and the induction time is derived. As a result of this study, the conclusion is that two‐step activity increases with increasing initial supersaturation or increasing salt concentration.

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“…Additionally, recent work by Allahyarov et al. provides evidence for a similar type of behavior with heterogeneous seeds which are present at the start of the crystallization process …”

Section: Resultsmentioning

confidence: 84%

The kinetics of homogeneous and two‐step nucleation during protein crystal growth from solution

Barlow¹,

Gregus

2019

Int J of Chemical Kinetics

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“…However, in many practical situations the wall is curved. Examples are provided by spherical obstacles or impurities which can act as a seed for heterogeneous nucleation, by porous materials with a lot of inner curved walls and cavities, and by a rough or patterned substrate [7,8]. This raises the question of the curvature dependence of the interfacial tension γ.…”

Section: Introductionmentioning

confidence: 99%

Hard rectangles near curved hard walls: Tuning the sign of the Tolman length

Sitta

Smallenburg

Wittkowski

et al. 2016

The Journal of Chemical Physics

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Combining analytic calculations, computer simulations, and classical density functional theory we determine the interfacial tension of orientable two-dimensional hard rectangles near a curved hard wall. Both a circular cavity holding the particles and a hard circular obstacle surrounded by particles are considered. We focus on moderate bulk densities (corresponding to area fractions up to 50 percent) where the bulk phase is isotropic and vary the aspect ratio of the rectangles and the curvature of the wall. The Tolman length, which gives the leading curvature correction of the interfacial tension, is found to change sign at a finite density, which can be tuned via the aspect ratio of the rectangles.

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“…In particular, they constitute an excellent system for the study of crystallisation, since they allow for the identification at the particle level of the structural changes and the kinetic processes that accompany the transition [4], both in the bulk [5][6][7][8] and in presence of interfaces [9][10][11][12][13][14]. In principle, it is possible to prepare density matched suspensions, where gravity plays no role and crystallisation stems from homogeneous or heterogeneous nucleation, depending on the boundary conditions of the experimental sample.…”

Section: Introductionmentioning

confidence: 99%

Crystallisation driven by sedimentation: a particle resolved study

Turci¹,

Royall²

2016

J. Stat. Mech.

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Abstract. We investigate the effects of the reversal of the gravitational field onto a sedimented and partially crystallised suspension of nearly-hard sphere colloids. We analyse the structural changes that take place during the melting of the crystalline regions and the reorganisation and assembly of the sedimenting particles. Through a comparison with numerical simulation, we access the single-particle kinetics and identify the key structural mechanism in the competition between five-fold symmetric and cubic crystalline structures. With the use of a coarse-grained, discrete model, we reproduce the kinetic network of reactions underpinning crystallisation and highlight the main microscopic transitions.

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Crystallization seeds favour crystallization only during initial growth

Cited by 69 publications

References 53 publications

The kinetics of homogeneous and two‐step nucleation during protein crystal growth from solution

The kinetics of homogeneous and two‐step nucleation during protein crystal growth from solution

Hard rectangles near curved hard walls: Tuning the sign of the Tolman length

Crystallisation driven by sedimentation: a particle resolved study

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