Crystallization of Piroxicam Solid Forms and the Effects of Additives

Liu, Guangpu; Hansen, Thomas Bruun; Qu, Haiyan; Yang, Mingshi; Pajander, Jari; Rantanen, Jukka; Christensen, Lars Porskjær

doi:10.1002/ceat.201400206

Cited by 20 publications

(33 citation statements)

References 28 publications

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“…It has been reported that the formation of different polymorphs/solvates of an API can be influenced by various operation parameters [1] [11], such as cooling profile, additives, operating mode (i.e. cooling or anti-solvent crystallization), solvents or solvent composition, and the concentration of solute used during the process.…”

Section: Introductionmentioning

confidence: 99%

Polymorphic behavior of isonicotinamide in cooling crystallization from various solvents

Hansen

Taris

Rong

et al. 2016

Journal of Crystal Growth

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Section: Introductionmentioning

confidence: 99%

Polymorphic behavior of isonicotinamide in cooling crystallization from various solvents

Hansen

Taris

Rong

et al. 2016

Journal of Crystal Growth

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“…Parameters such as the concentration and type of the additives can influence the occurrence of the different polymorphs [20][21][22]. The additives used for the crystallization process can influence the dissolution rate, the hardness, and therefore even the efficiency of the tablets [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Optimizing the Crystal Habit of Glycine by Using an Additive for Impinging Jet Crystallization

et al. 2017

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Additives selectively inhibit or enhance the growth of crystal faces and effectively change the crystal morphology. For the first time, potassium chloride was used as additive during impinging jet crystallization of glycine. The structure of the powder particles was evaluated by X-ray powder diffraction, differential scanning calorimetry, scanning electron microscopy with energy dispersive X-ray spectroscopy, headspace gas chromatography, and flame atomic absorption spectrometry. Even a minor amount of KCl had a significant effect on the crystal roundness and reduced the particle size significantly, despite of the extremely rapid nature of the crystallization process. This method resulted in the a-polymorph of glycine with an appropriate low residual additive content and a minimal residual organic solvent content. The arrangement and the optimal concentration of the additive were determined.

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“…Crystallization is a key technology used as a purification and isolation process both on a laboratory and an industrial scale in a wide variety of chemical engineering fields. The solids produced in crystallization processes based on different operation could have various physical and chemical properties such as CSD, crystal morphology, and solid‐state form, which have a strong effect on the final product properties, e.g., dissolution behavior, bioavailability, and density, as well as on the efficiency of the downstream processes such as filtration and drying , .…”

Section: Introductionmentioning

confidence: 99%

Solubility Study and Thermal Stability Analysis of Calcium Propionate

Lorenz

Seidel‐Morgenstern

2017

Chem Eng & Technol

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Solubilities in water and ethanol-water mixtures as well as the thermal behavior of the food additive calcium propionate were investigated to clarify deviations in published data. Material purified by recrystallization was used to exclude influence of impurities. Investigation of the dissociation process of calcium propionate in aqueous solution indicated that the particular shapes of the solubility curves cannot be attributed to changes in pH. The substance purchased turned out to be a mixture of the monohydrate and anhydrous calcium propionate. A new polymorph of the anhydrous calcium propionate was found and characterized. The results provide a better understanding of calcium propionate and support the development of improved crystallization processes. IntroductionCalcium propionate appears as a white crystalline solid or powder with odors resembling propionate acids [1, 2]. It is mainly used as preservative in a broad variety of products, especially in the manufacturing of baked goods. The antimicrobial action of calcium propionate is based on its dissociation process to produce undissociated propionate acid, which could diffuse across the cytoplasmic membrane. On the one hand it releases a proton to increase the energy consumption of the organism for removing the proton out, while on the other hand it accumulates in the cell and blocks metabolism by inhibiting enzymes [3]. Therefore, the pH value of the substance to be preserved is of great importance to the antimicrobial action [2].A typical concentration of calcium propionate used in bread production is 0.2 % based on the flour weight [4]. No flavor or lip feel is detectable when the concentration of calcium propionate in aqueous solutions ranges between 30 and 50 mM, which could be used with chlorinated water as a sanitary treatment for fresh-cut melon [5]. Calcium propionate is more widely used than propionic acid because it is easier to handle the solid salt than the corrosive liquid acid [3, 4]. The common method employed for the preparation of calcium propionate is the neutralization of propionic acid with calcium hydroxide in aqueous solution. The methods to achieve the solid products include spray drying, evaporation crystallization in aqueous solution or a solvent-free process, which could cause environment pollution and high costs or strong aggregation problems [6]. So, improving the solid-liquid separation process, which includes the design of an optimal crystallization process to produce calcium propionate with desired crystal size distribution (CSD), shape, and solid-state form as well as with low energy consumption and simplified procedures, is of crucial importance.Crystallization is a key technology used as a purification and isolation process both on a laboratory and an industrial scale in a wide variety of chemical engineering fields. The solids produced in crystallization processes based on different operation could have various physical and chemical properties such as CSD, crystal morphology, and solid-state form, which have a strong e...

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Crystallization of Piroxicam Solid Forms and the Effects of Additives

Cited by 20 publications

References 28 publications

Polymorphic behavior of isonicotinamide in cooling crystallization from various solvents

Polymorphic behavior of isonicotinamide in cooling crystallization from various solvents

Optimizing the Crystal Habit of Glycine by Using an Additive for Impinging Jet Crystallization

Solubility Study and Thermal Stability Analysis of Calcium Propionate

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