Crystallization of hydroxyapatite at physiological temperature

Ashok, Mahima; Sundaram, Narasimhan; Kalkura, S. Narayana

doi:10.1016/s0167-577x(02)01140-0

Cited by 105 publications

(70 citation statements)

References 8 publications

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“…The formation of apatite is confirmed with three diffraction maxima at 25.8, 31.8 and 53.4 (2θ°) corresponding to the (002), (211) and (004) apatite reflections [6] for 46S6. Concerning doped glasses, the (002) apatite reflection decreases in intensity compared to 46S6.…”

Section: Physico-chemical Resultsmentioning

confidence: 77%

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Effect of Copper and Zinc on the Bioactivity and Cells Viability of Bioactive Glasses

Wers¹,

Bunetel²,

Oudadesse³

et al. 2013

Bioceram Dev Appl

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Bioactive glasses, doped with traces of copper (Cu) and zinc (Zn) were synthesized by fusion method. Cu and Zn present interesting functions for the biological metabolism through their antibacterial, anti-inflammatory and antifungal properties. Several physical methods were employed to characterize the bioactive glasses before and after immersion in a Simulated Body Fluid (SBF). The "in vitro" experiments showed that after soaking in SBF, the behavior of bioactive doped glasses are different compared to pure glass 46S6. Obtained results show that glass matrix undergoes some changes after 15 days of immersion. The non toxic character of doped glasses was confirmed after 24 hours of incubation. The kinetic of release of Cu and Zn was carried out. It highlights that Cu is more released than Zn. By SEM, the morphology of hydroxyapatite obtained with Zn-doped glass show a better crystallization compared to Cu-doped glass. Effect of Copper and Zinc on the Bioactivity and Cells Viability of Bioactive GlassesWers E*, Bunetel L, Oudadesse H, Lefeuvre B, Lucas-Girot A, Mostafa A and Pellen P

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Section: Physico-chemical Resultsmentioning

confidence: 77%

“…Bioactive glasses are able to form a hydroxyapatite layer Ca 10 (PO 4 ) 6 (OH) 2 on their surface when they are immersed in a simulated body fluid. This formation induces a bone bonding improving the bone growth [1,2].…”

Section: Introductionmentioning

confidence: 99%

Effect of Copper and Zinc on the Bioactivity and Cells Viability of Bioactive Glasses

Wers¹,

Bunetel²,

Oudadesse³

et al. 2013

Bioceram Dev Appl

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“…Another mean to increase resorbability by the increase in the surface area is to produce porous granules. According to several authors 2,6,13,16,17 , pore diameter should be higher than 100ìm for the continued bone ingrowth. Furthermore, the quantity of new bone formed is directly proportional to pore size 4 .…”

Section: Discussionmentioning

confidence: 97%

“…Calcium phosphate (Ca-P) materials can be found in nature (coralline hydroxyapatite) or synthesized by precipitation methods using chemical reagents 1 . Hydroxyapatite, Ca 10 (PO 4 ) 6 (OH) 2 -HA, is the most well known and studied calcium phosphate. In medical and dental fields, the term "hydroxyapatite" is sometimes used to describe any calcium phosphate material.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical characterization of six commercial hydroxyapatites for medical-dental applicatons as bone graft

2005

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he aim of this work was to characterize six hydroxyapatites in granular form for applications in medicine and dentistry as bone graft and to compare with manufacturers´ specification. These samples were produced by four different manufacturers, and all of them are easily available in the Brazilian market. Physicochemical characterization was carried out by using electron microscopy (SEM), X-ray diffraction (XRD), infrared spectroscopy (FTIR) and surface area (BET) measurements. The results show that just one hydroxyapatite sample exhibited characterisitics in perfect agreement with the manufacturers' specifications. The studied parameters, namely crystallinity, surface area and composition may be used to estimate hydroxyapatite's biodegradability and as a criterion for quality control. Uniterms: Hydroxyapatite; Calcium phosphate; Bone graft; Physicochemical characterization. objetivo desse trabalho foi caracterizar seis hidroxiapatitas granulares para aplicação em área médico-odontológica como material de enxerto. Estes materiais foram produzidos por quatro diferentes fabricantes e são todos facilmente disponíveis no mercado brasileiro. A caracterização físico-química foi realizada por meio de microscopia eletrônica de varredura, difração de raios-X, espectroscopia de infravermelho e área superficial específica (BET). Os resultados mostraram que apenas um dos produtos teve a caracterização perfeitamente de acordo com a especificação do fabricante. Os parâmetros de cristalinidade, área superficial e composição podem ser usados para estimar a biodegradabilidade da hidroxiapatita e como critério de controle de qualidade desses materiais. Unitermos: Hidroxiapatita; Fosfato de cálcio; Enxerto ósseo; Caracterização físico-química.

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“…Moreover, after the physicochemical process to which the raw material was subjected to manufacture the product, the characteristic structure of this type of tissue could be maintained. Presence of pores and maintenance of the trabeculated crystalline structure of the bone are factors that are fundamental for achieving success in relation to cellular phenomena of deposition of osteoprogenitor cells on the graft, reabsorption of the graft and formation of new bone in its place (15,16) . Some authors have reported the same observations in relation to the microscopic structure, in commercial products subjected to thermal processes of deproteinization, such as BioOss or GenOx Inorg (10,11,17) , or to physicochemical processing not involving high temperatures, such as bovine TutoPlast, Tutobone or human TutoPlast (17) , and also in non-commercial products subjected to physicochemical processes of cleaning and purification such as OBM (10) or Kiel bone (17) .…”

Section: Discussionmentioning

confidence: 99%

Caracterização físico-química do enxerto de osso bovino liofilizado

Gália¹,

Lourenço²,

Rosito³

et al. 2011

Rev. bras. ortop.

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Objective: To evaluate the physicochemical characteristics of lyophilized bovine grafts manufactured on a semi-industrial scale (Orthogen; Baumer S/A*) in accordance with a protocol previously developed by the authors. Methods: The lyophilized bovine bone grafts were characterized by means of scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffractometry (XRD), thermogravimetric (TG) analysis, differential exploratory scanning calorimetry (DSC) and Fourier-transform infrared (FT-IR) spectroscopy. Results: Ca was the main component (60%) found in the samples, followed by P (28%) and O (5%). The mean (sd) pore size was 316 µm (146.7), ranging from 91.2 to 497.8 µm, andRev Bras Ortop. 2011;46(4):444-51

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Crystallization of hydroxyapatite at physiological temperature

Cited by 105 publications

References 8 publications

Effect of Copper and Zinc on the Bioactivity and Cells Viability of Bioactive Glasses

Effect of Copper and Zinc on the Bioactivity and Cells Viability of Bioactive Glasses

Physicochemical characterization of six commercial hydroxyapatites for medical-dental applicatons as bone graft

Caracterização físico-química do enxerto de osso bovino liofilizado

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