Crystallization Inhibition in Solid Dispersions of MK‐0591 and Poly(vinylpyrrolidone) Polymers

Evaluation of Drug-Polymer Miscibility in Amorphous Solid Dispersion Systems

“…5, where it can be observed that the carbonyl peak arising from ketoconazole in the solid dispersion is slightly lower than that predicted from the calculated physical mixture spectrum, a trend observed for all the dispersions. Changes in the relative height of the carbonyl peak of PVP have also been reported in literature (29), where the authors attributed this phenomenon to the ion-dipole interactions between PVP and their model compound. It is speculated that the differences in relative intensity for the ketoconazole-PVP system result from dipole-dipole type of interactions between ketoconazole and PVP molecules, since these species are incapable of forming hydrogen bond interactions.…”

Role of Thermodynamic, Molecular, and Kinetic Factors in Crystallization from the Amorphous State

“…[52][53][54][55][56][57][58] Matsumoto et al studied the isothermal crystallization of Indomethacin dispersed in PVP and Poly(vinyl pyrrolidone-covinyl-acetate) and found that at the level of polymers used in their study (5% w/w of all solid content), where the glass transition temperature was not affected and one may assume similar kinetic factors, inhibition of crystallization was controlled by hydrogen bonding of the polymer with Indomethacin. 55 In the study, no crystallization was observed in Indomethacin, over a 20 week period (at 308C), when different molecular weight polymers (PVP) were used at a 5% w/w level.…”

Effects of Polymer Type and Storage Relative Humidity on the Kinetics of Felodipine Crystallization from Amorphous Solid Dispersions

“…Since it has been shown that the crystallization rate of many APIs is retarded in the presence of the polymer (5)(6)(7)(8)(9)(10)(11), this method is commonly considered as a viable strategy to produce amorphous formulations with adequate physical stability. Oral delivery of an API in the amorphous form is highly attractive for some compounds and exploits the differences in physical properties of the amorphous solid compared to its crystalline counterpart(s).…”