Crystalline form B of risperidone

Wang, Danhua; Zhou, Minghua; Hu, Xiurong

doi:10.1107/s1600536806027930

Cited by 7 publications

(3 citation statements)

References 10 publications

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“…The rational design and synthesis of H 4 btec and analogous aromatic polycarboxylate metal complexes have attracted more and more attention in the fields of crystal engineering and material chemistry, not only because of their intriguing variety of crystal structures and topologies, [1][2][3][4][5][6][7][8][9][10] but also because of their potential applications in gas storage, [11][12][13] ion-exchange, [14,15] catalysis, [16,17] magnetism, [18][19][20][21] molecular sensing, [22] nonlinear optics, [23,24] and luminescence. [25,26] .…”

Section: Introductionmentioning

confidence: 99%

Hydrolytic Ring Opening Reactions of Pyromellitic Dianhydride for Divalent Transition Metal Carboxylate Complexes

Tao

Xia

Huang

et al. 2011

Zeitschrift anorg allge chemie

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The hydrolytic ring opening reactions of pyromellitic dianhydride is an effective method to prepare transition metal carboxylate complexes. In this paper, two dinuclear complexes [Ni 2 (2,2'-bipy) 2 -(btec)(H 2 O) 6 ]·2H 2 O (1) and [Cd 2 (phen) 4 (H 2 O) 2 (H 2 btec)]·H 2 btec·2H 2 O (2) (H 4 btec = 1,2,4,5-benzenetetracarboxylic acid, phen = 1,10-phenanthroline, and 2,2'-bipy = 2,2'-bipyridine) were synthesized by slow diffusion methods and their structures were determined by X-ray structure analysis. In both structures metal atoms are in distorted

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Section: Introductionmentioning

confidence: 99%

Hydrolytic Ring Opening Reactions of Pyromellitic Dianhydride for Divalent Transition Metal Carboxylate Complexes

Tao

Xia

Huang

et al. 2011

Zeitschrift anorg allge chemie

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“…All experimental peaks match those in the theoretical pattern generated from the known structure of risperidone form I [2] (refcode WASTEP). The theoretical pattern of form II [3] (refcode WASTEP01) contains a dominant peak at 21.78 ° and a distinctive region around 17-18 ° distinguishing it from form I, both of which are completely absent from all XRPD patterns collected. …”

Section: Solubilitymentioning

confidence: 99%

“…1. There are two reported polymorphs with crystal structures available in the Cambridge Structural Database (CSD) [2,3]. However, very limited data is available on the solid-liquid solubility of risperidone.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamics of risperidone and solubility in pure organic solvents

Mealey

Svärd

Rasmuson

2014

Fluid Phase Equilibria

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The solid-liquid solubility of the thermodynamically stable form I of the drug risperidone has been determined by a gravimetric method in nine pure organic solvents in the temperature range 278.15-323.15 K. The melting temperature and associated enthalpy of fusion of risperidone form I has been determined by differential scanning calorimetry (DSC) to be 442.38 K and 43.94 kJ mol -1 , respectively. The heat capacity of the solid form I and the melt have been determined over a range of temperatures by temperature-modulated DSC, and extrapolated data has been used to calculate the Gibbs energy, enthalpy and entropy of fusion from ambient temperature up to the melting point. The ideal solubility within a Raoult's law framework is obtained from the Gibbs energy of fusion, and the solution activity coefficient at equilibrium in the nine solvents quantified. Solutions in all solvents exhibit positive deviation from Raoult's law, with the highest solubility (closest to ideality) in toluene, an aprotic apolar solvent. The solubility curves plotted in a van't Hoff graph show non-linear behaviour and are well-approximated by a second order polynomial.

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DFT calculation of geometrical structure and electronic absorption spectra for neutral, mono-, and diprotonated forms of Risperidone (Risperdal)

Alparone

2012

J Appl Spectrosc

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Crystalline form B of risperidone

Abstract: Key indicatorsSingle-crystal X-ray study T = 298 K Mean (C-C) = 0.004 Å R factor = 0.064 wR factor = 0.151 Data-to-parameter ratio = 15.9For details of how these key indicators were automatically derived from the article, see

Cited by 7 publications

References 10 publications

Hydrolytic Ring Opening Reactions of Pyromellitic Dianhydride for Divalent Transition Metal Carboxylate Complexes

Hydrolytic Ring Opening Reactions of Pyromellitic Dianhydride for Divalent Transition Metal Carboxylate Complexes

Thermodynamics of risperidone and solubility in pure organic solvents

DFT calculation of geometrical structure and electronic absorption spectra for neutral, mono-, and diprotonated forms of Risperidone (Risperdal)

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