Crystal structures of two decavanadates(V) with pentaaquamanganese(II) pendant groups: (NMe4)2[V10O28{Mn(H2O)5}2]·5H2O and [NH3C(CH2OH)3]2[V10O28{Mn(H2O)5}2]·2H2O

Franco, Mônica Regina; Rüdiger, André Luis; Soares, Jaı́sa F.; Nunes, Giovana G.; Hughes, David L.

doi:10.1107/s2056989014028230

Cited by 6 publications

(6 citation statements)

References 23 publications

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“…A good agreement between simulated and experimental data was obtained for solid decavanadate, upon fitting the presently measured EXAFS results on the basis of the reported structure for crystal decavanadate 49 (Table 3 and Figure 2).…”

Section: Resultssupporting

confidence: 68%

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An EXAFS Approach to the Study of Polyoxometalate–Protein Interactions: The Case of Decavanadate–Actin

et al. 2017

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EXAFS and XANES experiments were used to assess decavanadate interplay with actin, in both the globular and polymerized forms, under different conditions of pH, temperature, ionic strength, and presence of ATP. This approach allowed us to simultaneously probe, for the first time, all vanadium species present in the system. It was established that decavanadate interacts with G-actin, triggering a protein conformational reorientation that induces oxidation of the cysteine core residues and oxidovanadium (V) formation. The local environment of vanadium's absorbing center in the [decavanadate-protein] adducts was determined, a V-S coordination having been verified experimentally. The variations induced in decavanadate's EXAFS profile by the presence of actin were found to be almost totally reversed by the addition of ATP, which constitutes a solid proof of decavanadate interaction with the protein at its ATP binding site. Additionally, a weak decavanadate interplay with F-actin was suggested to take place, through a mechanism different from that inferred for globular actin. These findings have important consequences for the understanding, at a molecular level, of the significant biological activities of decavanadate and similar polyoxometalates, aiming at potential pharmacological applications.

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Section: Resultssupporting

confidence: 68%

“… a CN denotes coordination number. b Debye–Waller factor. c Original distances d V–ligand distances refined by the EXAFS fit: χ 2 = 1139; reduced χ 2 = 282; R factor 0.039.…”

Section: Resultsmentioning

confidence: 99%

An EXAFS Approach to the Study of Polyoxometalate–Protein Interactions: The Case of Decavanadate–Actin

et al. 2017

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“…This compound has therapeutic properties as a hypoglycemic, lipid-lowering and metabolic regulator [79]. Considering other promising biological roles of these kinds of compounds, several groups reported novel synthesis of different polyoxovanadates based on decavanate structure [80,81].…”

Section: Polyoxovanadate Compoundsmentioning

confidence: 99%

Vanadium, Ruthenium and Copper Compounds: A New Class of Nonplatinum Metallodrugs with Anticancer Activity

León

Cadavid-Vargas²,

Virgilio³

et al. 2017

CMC

123

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Cancer is a group of diseases involving abnormal cell growth. The cells grow uncontrollably with the potential to invade and spread to other parts of the body. This disease is one of the principal death causes in the world, thus becoming a significant topic of scientific research. On the other hand, transition metals play a fundamental role in different living systems. In particular, Metallodrugs represent new and powerful tools for diverse therapeutic applications. To date, various metallodrugs display interesting biological activities for chemotherapy. In this field, cisplatin was the first inorganic compound with high relevance in cancer treatment. This compound was a leader agent in clinical use. Toxicity and resistance problems trigger the development of other platinum drugs with better clinical perspective and also raise the scientific interest for the putative antitumor properties of V, Ru and Cu compounds. Several scientific articles show that complexes of these metals are the new metal-based drugs used in the treatment of several cancers, such us, lung, colon, breast, bladder, etc. In this review we recapitulate current information and new advances on antitumor in vitro effects of several organic and inorganic compounds derived from copper, ruthenium and vanadium. These metal derived compounds targeting DNA or cell proteins involved in cell signaling pathways related to cancer. The mechanisms of cell death of these metallodrugs have also been comprehensibly reviewed. The knowledge of these mechanisms of death and the relationship between chemical structure and biological activity may be useful for the design of new metal-based drugs with promising pharmacologic applications as anticancer agents.

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“…The slightly irregular octahedral coordination sphere of the Co1 atom is completed by one oxygen atom O1 coming from the terminal VQO group of the decavanadate (atom O F in Scheme 1). Such a coordination fashion is not unknown and was already reported for manganese(II) 72,76 and zinc(II) derivatives. 68,69 The bond length O1-Co1 2.089(3) Å indicates a relatively strong coordination bond of decavanadate to the metal centre.…”

Section: Crystal Structuresmentioning

confidence: 60%

Tuning the interactions of decavanadate with thaumatin, lysozyme, proteinase K and human serum proteins by its coordination to a pentaaquacobalt(ii) complex cation

2019

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Crystal structures of two decavanadates(V) with pentaaquamanganese(II) pendant groups: (NMe₄)₂[V₁₀O₂₈{Mn(H₂O)₅}₂]·5H₂O and [NH₃C(CH₂OH)₃]₂[V₁₀O₂₈{Mn(H₂O)₅}₂]·2H₂O

Cited by 6 publications

References 23 publications

An EXAFS Approach to the Study of Polyoxometalate–Protein Interactions: The Case of Decavanadate–Actin

An EXAFS Approach to the Study of Polyoxometalate–Protein Interactions: The Case of Decavanadate–Actin

Vanadium, Ruthenium and Copper Compounds: A New Class of Nonplatinum Metallodrugs with Anticancer Activity

Tuning the interactions of decavanadate with thaumatin, lysozyme, proteinase K and human serum proteins by its coordination to a pentaaquacobalt(ii) complex cation

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