Crystal Structures ofβ-Cyclodextrin Complexes with Formic Acid and Acetic Acid

Antimicrobial films based on cellulose-derived hydrocolloids. A synergetic effect of host–guest interactions on quality and functionality

“…Analysis of the films' DTA graphs showed that release of the water content when β-CD was present was delayed to higher temperatures. This suggests that β-CD holds water by creating hydrogen bonds with its hydroxyl groups [26]. As the temperature increased, the thermograms revealed the decomposition profile of the films.…”

“…β-cyclodextrin (β-CD), much like the rest of the CD family, is a cyclic oligosaccharide with a hydrophobic cavity and an outer hydrophilic surface and is widely used to encapsulate lipophilic compounds [24,25]. However, interactions of β-CD with hydrophilic guest molecules remained out of scientific literary focus and are scarcely explored [26].…”

Improving cyclodextrin complexation of a new antihepatitis drug with glacial acetic acid

“…Aree et al 21 have reported that acetic acid forms an inclusion complex with cyclodextrin when HPβCD is dissolved in 10% acetic acid and allowed to recrystallize through slow solvent evaporation. It is unknown whether the residual acetic acid present in the proposed dry powder formulation is part of the complex.…”

“…However, the fact that the remaining acetic acid was not easily removed combined with the final stoichiometric ratio of 2 acetic acid molecules per cyclodextrin molecule, suggests that the acetic acid is, to some degree, involved in the complex. Through x-ray diffraction, Aree et al 21 have shown that a complex between HPβCD and acetic acid can be accomplished through hydrogen bonding. They show that the acetic acid carboxyl hydrogen bonds with the hydroxyl groups of the cyclodextrin while the 2 carbons of the acid are positioned inside the nonpolar cavity.…”

“…Based on the data of Aree et al, 21 it is possible that the aromatic ring of the PG301029 is snugly enmeshed between the 2 carbon chains of 2 acetic acid molecules and that a network of hydrogen bonds readily occurs between the 2 carboxyls, the cyclodextrin hydroxyls, and the PG301029 amines. Furthermore, it is possible that the presence of the acetic acid molecules in the complex shields the PG301029 molecule from aqueous degradation.…”