Crystal structures of 3-fluoro-N-[2-(trifluoromethyl)phenyl]benzamide, 3-bromo-N-[2-(trifluoromethyl)phenyl]benzamide and 3-iodo-N-[2-(trifluoromethyl)phenyl]benzamide

Abstract

The crystal structures of three N-[2-(tri­fluoro­meth­yl)phen­yl]benzamides are reported. The 3-fluoro­benzamide crystallized with two independent mol­ecules in the asymmetric unit; the dihedral angles between the two benzene rings are 43.94 (8) and 55.66 (7)°. In the 3-bromo­benzamide and the 3-iodo­benzamide, this dihedral angle is much smaller, viz. 10.40 (12) and 12.5 (2)°, respectively.

Structural analysis of 2-iodobenzamide and 2-iodo-N-phenylbenzamide

“…Aromatic amides can be found in a wide range of aromatic molecules and they also serve as intermediates in the production of many pharmaceutical compounds (Suchetan et al, 2016). Aromatic amides and N-aryl amides display a wide spectrum of pharmacological properties and are used as antibacterial (Ragavan et al, 2010), analgesic (Starmer et al, 1971), antiviral (Hu et al, 2008), anti-inflammatory (Kalgutkar et al, 2000) and anti-cancer (Pradidphol et al, 2012) agents.…”