Crystal structures, in situ synthesis in aqua conditions and luminescent properties of benzimidazole ligands and cadmium coordination complexes

Ou, Yong-Cong; Chen, Chenghan; Liang, Yuanhao; Tang, Junjie; Feng, Shao-Bin; Liang, Peng; Wu, Jian‐Zhong

doi:10.1016/j.ica.2015.07.006

Cited by 8 publications

(1 citation statement)

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“…In recent years, a great effort has been devoted to the selfassembly of inorganic molecules in the solid state, because it allows the design of new solids with specific properties, especially playing an important role in bio-inorganic, coordination and medicinal inorganic chemistry. In situ metal-ligand synthesis reactions have attracted continuous attention in recent years, because they, as a bridge between coordination chemistry and organic chemistry, may simplify the synthesis and purification of organic ligands and/or the construction of new coordination complexes (Hayashi, 2016;Ou et al, 2015;Tan et al, 2022;Zhang, 2005).…”

Section: Introductionmentioning

confidence: 99%

An efficient one-pot synthesis of pyrazole complexes formed in situ: synthesis, crystal structure, Hirshfeld surface analysis and in vitro biological properties

Adach,

Tyszka-Czochara,

Daszkiewicz

2023

Acta Crystallogr C

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The molecular crystals of monomeric and dimeric pyrazole complexes were prepared via one-pot syntheses. These are dichloridobis(3,5-dimethyl-1H-pyrazole-κN 1)cobalt/zinc(0.2/0.8), [Co0.20Zn0.80Cl2(C5H8N2)2] or [Co0.2Zn0.8Cl2(3,5-dmp)2] (1), and bis(μ-3,5-dimethyl-1H-pyrazole)-κ2 N 1:N 2;κ2 N 2:N 1-bis[bromido/chlorido(0.7/0.3)bis(3,5-dimethyl-1H-pyrazole-κN 1)cobalt/zinc(0.1/0.9)], [Co0.20Zn1.80Br1.40Cl0.60(C5H7N2)2(C5H8N2)2] or [Co0.1Zn0.9Br0.7Cl0.3(μ-3,5-dmp)(3,5-dmp)]2 (2). The isolated complexes contain 3,5-dimethylpyrazole (3,5-dmp) ligands formed in situ from the decomposition of 1-hydroxymethyl-3,5-dimethylpyrazole. In both isolated complexes, some positional disorder is observed at the metal ions and halogen ligands. The molecular crystals of 1 and 2 are centrosymmetric, with the space groups C2/c and P-1, respectively. Additionally, in the dinuclear complex, the pyrazole ring has a bridging coordination function with respect to the metal ions. Both complexes have good biological activities against cancer cells. The results of an in vitro cytotoxicity study indicated that compounds 1 and 2 showed significant cytotoxicity for cancer cell lines, including hepatic (HepG2 cells), lung (A549 cells) and colon cancer cells (SW 480 and SW 620). Based on the calculated IC50 values against human cancer cell lines, it was found that both complexes demonstrated potent antiproliferative activity combined with great selectivity towards cancer cells. Complex 2 was a more effective cytotoxic agent which, at the same time, exhibited high cytocompatibility. The obtained data are very encouraging and could be useful for anticancer drug discovery.

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Section: Introductionmentioning

confidence: 99%