Crystal structures and cytotoxicity of isopropylamine Pt(II) complexes: A trinuclear squarato-bridged [Pt3(μ2-C4O4)3(H2NPr )6] · 3H2O and a mononuclear cis-[Pt(NO3)2(H2NPr )2]

Grabner, Sabina; Modec, Barbara; Čemažar, Maja; Bukovec, N.

doi:10.1016/j.jinorgbio.2005.04.004

Cited by 9 publications

(1 citation statement)

References 27 publications

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“…), and 3-(hydroxymethyl)-and 4-(hydroxymethyl)pyridines were purchased from common vendors. cis-[PtI 2 (NH 3 ) 2 ] and cis-[PtI 2 (NH 2 CH(CH 3 ) 2 )] were prepared according to published procedures [6] [10], slight modifications were used according to [11]. The 1 H-, 13 C-, and 195 Pt-NMR spectra were recorded on a Bruker AMX-300 instrument.…”

Section: Experimental Partmentioning

confidence: 99%

Influence of (Hydroxymethyl)pyridine and Pyridine‐carboxylic Acids, in trans‐Position to the Isopropylamine and Ammine Ligands, on the Cytotoxicity of Platinum Complexes

Medina

Rodriguez

Quiroga

et al. 2008

Chemistry & Biodiversity

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trans-Pt(II) Complexes with aliphatic amines and planar amines such as (hydroxymethyl)pyridines, and pyridine-3- and pyridine-4-carboxylic acids were synthesized and screened for their potential cytotoxic activity in different cancer cell lines used at the NCI for in vitro screens, i.e., MCF7, NCIH460, and SF268. The complexes studied were designed to differ in geometrical parameters such as the position of the phenyl-group substituents and the nature of the substituents themselves for gathering information about the structure-activity relationships in the trans-complexes. The variation of the substituents turns to be crucial for their biological activity, as both pyridine-3- and pyridine-4-carboxylic acids in trans-position to both amine and isopropylamine ligands provided complexes which displayed no specificity toward any type of cell tested, while (hydroxymethyl)pyridine in trans-position to isopropylamine ligands led to complexes that were clearly more effective against the cell lines tested.

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Section: Experimental Partmentioning

confidence: 99%

Influence of (Hydroxymethyl)pyridine and Pyridine‐carboxylic Acids, in trans‐Position to the Isopropylamine and Ammine Ligands, on the Cytotoxicity of Platinum Complexes

Medina

Rodriguez

Quiroga

et al. 2008

Chemistry & Biodiversity

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Synthesis of Metal Enolato Complexes

Vicente

2010

Patai's Chemistry of Functional Groups

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Introduction Synthesis from Ketones, Aldehydes and Esters Synthesis from Ketenes, Isocyanates and Acyl Halides Synthesis from Carbon Monoxide and Carbonyl Complexes Synthesis via Cleavage of Ethers and Related Compounds Synthesis from Oxo, Hydroxo or Alkoxo Complexes Oxygenation Reactions Miscellaneous Reactions Acknowledgments

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Platinum(IV) Complexes of 3‐ and 4‐Picolinic Acids Containing Ammine or Isopropylamine Ligands – Synthesis, Characterization, X‐ray Structures, and Evaluation of Their Cytotoxic Activity against Cancer Cell Lines

et al. 2008

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Crystal structures and cytotoxicity of isopropylamine Pt(II) complexes: A trinuclear squarato-bridged [Pt3(μ2-C4O4)3(H2NPr )6] · 3H2O and a mononuclear cis-[Pt(NO3)2(H2NPr )2]

Cited by 9 publications

References 27 publications

Influence of (Hydroxymethyl)pyridine and Pyridine‐carboxylic Acids, in trans‐Position to the Isopropylamine and Ammine Ligands, on the Cytotoxicity of Platinum Complexes

Influence of (Hydroxymethyl)pyridine and Pyridine‐carboxylic Acids, in trans‐Position to the Isopropylamine and Ammine Ligands, on the Cytotoxicity of Platinum Complexes

Synthesis of Metal Enolato Complexes

Platinum(IV) Complexes of 3‐ and 4‐Picolinic Acids Containing Ammine or Isopropylamine Ligands – Synthesis, Characterization, X‐ray Structures, and Evaluation of Their Cytotoxic Activity against Cancer Cell Lines

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Crystal structures and cytotoxicity of isopropylamine Pt(II) complexes: A trinuclear squarato-bridged [Pt3(μ2-C4O4)3(H2NPr )6] · 3H2O and a mononuclear cis-[Pt(NO3)2(H2NPr )2]

Cited by 9 publications

References 27 publications

Influence of (Hydroxymethyl)pyridine and Pyridine‐carboxylic Acids, in trans‐Position to the Isopropylamine and Ammine Ligands, on the Cytotoxicity of Platinum Complexes

Influence of (Hydroxymethyl)pyridine and Pyridine‐carboxylic Acids, in trans‐Position to the Isopropylamine and Ammine Ligands, on the Cytotoxicity of Platinum Complexes

Synthesis of Metal Enolato Complexes

Platinum(IV) Complexes of 3‐ and 4‐Picolinic Acids Containing Ammine or Isopropylamine Ligands – Synthesis, Characteri­zation, X‐ray Structures, and Evaluation of Their Cytotoxic Activity against Cancer Cell Lines

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Platinum(IV) Complexes of 3‐ and 4‐Picolinic Acids Containing Ammine or Isopropylamine Ligands – Synthesis, Characterization, X‐ray Structures, and Evaluation of Their Cytotoxic Activity against Cancer Cell Lines