Crystal Structures and Antimicrobial Activities of N'-[2,5-Dihydroxybenzylidene]-3,4,5-Trimethoxybenzohydrazide, N'-[2,4-Dichlorobenzylidene]-3,4,5-Trimethoxybenzohydrazide, and 2,4-Dichloro-N'-(2-Hydroxy-3-Methoxy-5-Nitrobenzylidene)benzohydrazide Ethanol Solvate

Abstract

Three benzohydrazone compounds,4,4,, and 2,4-dichloro-N'-(2-hydroxy-3-methoxy-5-nitrobenzylidene)benzohydrazide ethanol solvate (3), have been synthesized and structurally characterized by elemental analysis and X-ray single crystal structure determination. Compound (1) (3) showed the most effective activity against Escherichia coli, which is even stronger than the controlled drug Tetracycline.