Crystal structure of the drug-discharge outer membrane protein, OprM

Akama, Hiroyuki; Kanemaki, Misa; Yoshimura, Masashi; Tsukihara, Tomitake; Kashiwagi, T.; Narita, Shin‐ichiro; Nakagawa, Atsuko; Nakae, Takashi

doi:10.2210/pdb1wp1/pdb

2004

DOI: 10.2210/pdb1wp1/pdb

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Crystal structure of the drug-discharge outer membrane protein, OprM

Hiroyuki Akama¹,

Misa Kanemaki²,

Masashi Yoshimura³

et al.

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The extracellular vesicle generation paradox: a bacterial point of view

McMillan

Kuehn

2021

The EMBO Journal

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All bacteria produce secreted vesicles that carry out a variety of important biological functions. These extracellular vesicles can improve adaptation and survival by relieving bacterial stress and eliminating toxic compounds, as well as by facilitating membrane remodeling and ameliorating inhospitable environments. However, vesicle production comes with a price. It is energetically costly and, in the case of colonizing pathogens, it elicits host immune responses, which reduce bacterial viability. This raises an interesting paradox regarding why bacteria produce vesicles and begs the question as to whether the benefits of producing vesicles outweigh their costs. In this review, we discuss the various advantages and disadvantages associated with Gram-negative and Gram-positive bacterial vesicle production and offer perspective on the ultimate score. We also highlight questions needed to advance the field in determining the role for vesicles in bacterial survival, interkingdom communication, and virulence.

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The extracellular vesicle generation paradox: a bacterial point of view

McMillan

Kuehn

2021

The EMBO Journal

View full text Add to dashboard Cite

show abstract

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Crystal structure of the drug-discharge outer membrane protein, OprM

Cited by 1 publication

References 0 publications

The extracellular vesicle generation paradox: a bacterial point of view

The extracellular vesicle generation paradox: a bacterial point of view

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