Crystal structure of Synechococcus elongatus 6-4 photolyase suggests a novel repairing mechanism
Lei Xu,
Wei Zhang,
Yaqi Liu
et al.
Abstract:SePhrB provides the first structure of prokaryotic 6 − 4 photolyases with 8-HDF as the antenna cofactor, and also the first structure of photolyases with covalently-linked FAD as the catalytic cofactor. It also contains a [4Fe-4S] cluster coordinated with four conserved cysteine residues. Based on the structural analysis and the inspiration of a study on human primase27, we propose that the [4Fe-4S] cluster in SePhrB may participate in electron transfer and trigger DNA disassociation during catalysis. The bind… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.