Crystal structure of nitarsone determined from synchrotron X-ray powder diffraction data

Substituted phenylarsonic acids; structures and spectroscopy

“…The -NH 2 group acts as an acceptor to an As-OH from As(1) molecules, and as an N-H donor to the O of an As-O-H of As (3) molecules. The 8/12-membered alternating ring motif was also found for 4-NO 2 -C 6 H 4 AsO 3 H 2 , though with a small variation in the 12-membered ring [28].…”

Organic Solvent-Free Reversed-Phase Ion-Pairing Liquid Chromatography Coupled to Atomic Fluorescence Spectrometry for Organoarsenic Species Determination in Several Matrices

“…and anthropogenic sources . On the other hand, a number of phenylarsonic compounds (PheAs), including Roxarsone (ROX), p -arsanilic acid ( p -ASA) and nitarsone (NIT), have been used as additives to chicken and swine feed. − ROX (3-nitro-4-hydroxyphenylarsonic acid) and p -ASA (4-aminophenylarsonic acid) are normally used to prevent and treat coccidiosis in poultry, improve weight gain, promote growth by providing improved feed conversion, better feathering and increased egg production and pigmentation. − These PheAs are widely used in the USA and China as growth promoters in broilers and pigs. , NIT is the drug of choice for the prevention and treatment of histomoniasis, a disease caused by protozoan . Although a fraction of ingested PheAs is retained in chicken or pork, they are mainly excreted. ,, Therefore, it can be stated that repeated annual poultry litter applications to agricultural soils may result in As buildup in soil, leading to plant uptake and subsequent transfer to the human food chain or leaching to groundwater. , …”

“…5,8 NIT is the drug of choice for the prevention and treatment of histomoniasis, a disease caused by protozoan. 9 Although a fraction of ingested PheAs is retained in chicken or pork, they are mainly excreted. 8,10,11 Therefore, it can be stated that repeated annual poultry litter applications to agricultural soils may result in As buildup in soil, leading to plant uptake and subsequent transfer to the human food chain or leaching to groundwater.…”

Powder X-ray study of racemic (2RS,3RS)-5-amino-3-[4-(3-methoxyphenyl)piperazin-1-yl]-1,2,3,4-tetrahydronaphthalen-2-ol

“…This involves a 26-atom (non-H) problem, which requires careful measurement and interpretation of the data in order to optimize the quality of the results. In recent years, the crystal structures of a number of compounds of pharmaceutical interest have been determined by powder X-ray diffraction data as a last resort in the absence of single crystals of sufficient quality (Chan et al, 1999;Shankland et al, 2004;Chernyshev et al, 2003;Kiang et al, 2003;Rukiah et al, 2004;Van der Lee et al, 2005;Rukiah & Assaad, 2010…”