Crystal Structure of NADPH-Dependent Methylglyoxal Reductase Gre2 from Candida Albicans

Nguyen, Giang T.; Kim, Shinae; Jin, Hyeonseok; Cho, Dong‐Hyung; Chun, Hang-Suk; Kim, Woo‐Keun; Chang, Jeong Ho

doi:10.3390/cryst9090471

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…Other aldehyde dehydrogenases may also catalyze this reaction in the presence of GSH. Methylglyoxal reductase relies on NADPH or NADH to reduce MG to lactaldehyde, which may then be converted to acetol. , In E. coli , MG is directly converted to acetol through the activity of an NADPH-dependent aldehyde reductase and NADH-dependent alcohol dehydrogenase . There are several receptors that mediate the degradation of MG-AGEs to counteract oxidative stress through endocytosis and removal, including AGE-specific receptors (AGER1, AGER2, and AGER3) and CD36. − …”

Section: Defense Mechanisms Against Electrophiles and Repair/removal ...mentioning

confidence: 99%

Diet and Obesity-Induced Methylglyoxal Production and Links to Metabolic Disease

Hernandez-Castillo

Shuck

2021

Chem. Res. Toxicol.

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The obesity rate in the United States is 42.4% and has become a national epidemic. Obesity is a complex condition that is influenced by socioeconomic status, ethnicity, genetics, age, and diet. Increased consumption of a Western diet, one that is high in processed foods, red meat, and sugar content, is associated with elevated obesity rates. Factors that increase obesity risk, such as socioeconomic status, also increase consumption of a Western diet because of a limited access to healthier options and greater affordability of processed foods. Obesity is a public health threat because it increases the risk of several pathologies, including atherosclerosis, diabetes, and cancer. The molecular mechanisms linking obesity to disease onset and progression are not well understood, but a proposed mechanism is physiological changes caused by altered lipid peroxidation, glycolysis, and protein metabolism. These metabolic pathways give rise to reactive molecules such as the abundant electrophile methylglyoxal (MG), which covalently modifies nucleic acids and proteins. MG-adducts are associated with obesity-linked pathologies and may have potential for biomonitoring to determine the risk of disease onset and progression. MG-adducts may also play a role in disease progression because they are mutagenic and directly impact protein stability and function. In this review, we discuss how obesity drives metabolic alterations, how these alterations lead to MG production, the association of MG-adducts with disease, and the potential impact of MG-adducts on cellular function.

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Section: Defense Mechanisms Against Electrophiles and Repair/removal ...mentioning

confidence: 99%

Diet and Obesity-Induced Methylglyoxal Production and Links to Metabolic Disease

Hernandez-Castillo

Shuck

2021

Chem. Res. Toxicol.

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“…Their study provided invaluable insights for the development of potent inhibitors towards pathogenic microorganisms. This group also determined the crystal structures of an NADPH-dependent methylglyoxal reductase in apo-and NADPH-complexed form [7]. As a key enzyme in the methylglyoxal detoxification pathway, it can reduce directly the level of cytotoxic methylglyoxal.…”

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confidence: 99%

Crystallographic Studies of Enzymes

Kim

2019

Crystals

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Enzymes are biological catalysts, which work to accelerate chemical reactions at the molecular level in living organisms. They are major players in the control of biological processes such as replication, transcription, protein synthesis, metabolism, and signaling. Like inorganic catalysts, enzymes function by decreasing the activation energy of chemical reactions, thereby enhancing the rate of the reactions. Enzymes are widely used for chemical, food, pharmaceutical, medicinal, analytical, clinical, forensic, and environmental applications. Therefore, studies on their structure, mechanism, and function, using a wide range of experimental and computational methods, are necessary to understand better enzymes in biological processes. For this special issue, “Crystallographic Studies of Enzymes", we have collected research papers on enzymes with structural aspects and functional aspects; here we briefly discuss the contents of such research papers as follows, with the aim of suggesting new directions of investigation in the fields of enzyme research, protein engineering, and drug development.

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Structural behavior and surface layer modification of (E)-N'-((1H-indol-3-yl) methylene)-4-chlorobenzohydrazide: Spectroscopic, DFT, biomedical activity and molecular dynamic simulation against Candida Albicans receptor

Ibraheem,

Issa,

El-Sayed

2024

Journal of Molecular Structure

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Crystal Structure of NADPH-Dependent Methylglyoxal Reductase Gre2 from Candida Albicans

Cited by 4 publications

References 33 publications

Diet and Obesity-Induced Methylglyoxal Production and Links to Metabolic Disease

Diet and Obesity-Induced Methylglyoxal Production and Links to Metabolic Disease

Crystallographic Studies of Enzymes

Structural behavior and surface layer modification of (E)-N'-((1H-indol-3-yl) methylene)-4-chlorobenzohydrazide: Spectroscopic, DFT, biomedical activity and molecular dynamic simulation against Candida Albicans receptor

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