Crystal Structure of N,N-bis-(3-Carbomethoxy-5-methyl-pyrazol-1-ylmethyl)aniline

Abstract

The tripodal ligand N,N-bis-(3-carbomethoxy-5-methylpyrazol-1-yl)methyl aniline (2) has been prepared by the condensation of aniline with two equivalents of N-hydroxymethyl[3-carbomethoxy-5-methyl]pyrazole. The molecule consists of two structurally analogous 3-carbomethoxy-5-methylpyrazol-1-ylmethyl moieties, which adopt a transoidal conformation via a central aniline ring, suggesting that this tripodal ligand is highly flexible and could accommodate many metals by coordination.

Synthesis and Cytotoxicity of Bis‐1,3,4‐oxadiazoles and Bis‐pyrazoles Derived from 1,4‐Bis[5‐thio‐4‐substituted‐1,2,4‐triazol‐3‐Yl]‐butane and Their DNA Binding Studies

“…The bis-1,3,4-oxadiazole-5-thiones 7-12 were synthesized from intermediate acid hydrazides by refluxing with excess of carbon disulfide and potassium hydroxide. Similarly the acid hydrazides on heating with excess of acetyl acetone yielded 1,4-bis[5-(1-oxo-1-(3,5 dimethyl pyrazol-1-yl)-methyl)-thio-4-substitued-1,2,4-triazol-3-yl]-butane [13][14][15][16][17][18]. The list of compounds synthesized is given in Table 1 along with corresponding melting points and lipophilicity values.…”

“…Many of the bis-1, 2, 4-triazoles [13][14][15][16], bis-oxadiazoles [17], and bis-pyrazoles [18,19] have also been reported to possess wide spectrum of biological activity. Keeping these observations in mind and in continuation of our work on the synthesis of bis-heterocyclic compounds [20]; we report herein the synthesis and in-vitro cytotoxic activity of certain novel oxadiazole and pyrazole incorporated bis-1,2,4-triazoles separated by a butyl side chain.…”