Crystal Structure of (I)Trimebutine Trihydrogenodimaleate.

Gicquel-Mayer, C.; Coquerel, Gérard; Petit, Marie‐Noëlle; Bouazlz, Roger; Robert, Françis

doi:10.2116/analsci.9.557

Cited by 2 publications

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“…5 The two hydrogeno maleic acid and the doubly protonated maleic acid are linked by a classical dimeric -COOH--HOOCbond, identical to the one found in the crystal structure of the pure maleic acid (Figure 13.7). It has been tempting to test the pentahydrogenotrimaleate or an even higher homologue in this series but no other solid phase has been detected.…”

Section: Example 2: Trimebutine Maleatesupporting

confidence: 52%

Limits of the Co-crystal Concept and Beyond

Coquerel

2011

Pharmaceutical Salts and Co-Crystals

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In this chapter, views of co-crystals are broadened. Indeed, any classification has its limits and, clearly, the thermodynamics of heterogeneous equilibria can help to replace the concept of the co-crystal in a more general perspective. Co-crystals are nothing other than intermediate compounds. Nevertheless, the concept suffers from intrinsic uncertainties due to the numerous situations in which they can occur such as the continuum between solvate and co-crystals, hybrid salt-co-crystals, multi-epitaxy and so on. It is even possible to find the same partners with simultaneously salt-like and co-crystal-like relationships in a given crystal structure. Therefore, rather than creating questionable terms and maintaining endless semantic debates with poor added value, the scientific community should concentrate more on the three long lasting problems related to intermediate compounds listed below: 1. Prediction of intermediate compounds: indeed, apart from statistical trends (e.g. racemic compounds as detailed in this chapter), there is no way to predict the existence of an intermediate compound with acceptable reliability. 2. Prediction of the attributes of these intermediate compounds: to date the connection between structures and properties is very weak despite the evident interest. 3. How to design a process to obtain those intermediate phases with a good yield and minimum side products? Moreover these processes should fulfil the specifications for the final products such as crystallinity, crystal size distribution, morphology, and so on. These questions are really meaningful from an industrial perspective and for advancing knowledge in the organic solid state.

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Section: Example 2: Trimebutine Maleatesupporting

confidence: 52%

Limits of the Co-crystal Concept and Beyond

Coquerel

2011

Pharmaceutical Salts and Co-Crystals

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Preferential Crystallization

Coquerel

2006

Topics in Current Chemistry

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132

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This contribution focuses primarily on chiral discrimination in the solid state, i.e. the formationof conglomerates, how to detect them and the various benefits that can be retrieved from chiral recognitionin crystal lattices.The core of the work is devoted to phase diagrams (mainly binary and ternary). The stable and metastableheterogeneous equilibria are depicted and used to understand different variants of preferential crystallizationand how the entrainment effect proceeds. Seeded and auto-seeded processes are analyzed minutely. The seedingprocedure has a significant impact on the control of stereoselective secondary nucleation and crystalgrowth.The review ends with a systematic analysis of the reasons that can put, sometimes, severe limitationson the entrainment effect.

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Crystal Structure of (I)Trimebutine Trihydrogenodimaleate.

Cited by 2 publications

References 1 publication

Limits of the Co-crystal Concept and Beyond

Limits of the Co-crystal Concept and Beyond

Preferential Crystallization

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