Crystal Structure of Ferrihydrite Nanoparticles Synthesized in Ferritin

Kim, Sung-Won; Seo, Hyang-Yim; Lee, Young-Boo; Park, Young-Seog; Kim, Kyung-Suk

doi:10.5012/bkcs.2008.29.10.1969

Cited by 17 publications

(1 citation statement)

References 17 publications

(17 reference statements)

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“…This is a well-known mechanism, producing the "asbestos bodies", often detected around the longest fibers in the tissues of the respiratory system and considered markers for exposure to asbestos. The covering is made by iron-proteins, affecting parts or the whole fiber, and it constitutes a way to isolate the foreign material from the biological medium [25,26]. In the fiber shown in Figure 1a, the covering process is at a first step, being evident and well-formed only in the central part of the long fiber.…”

Section: Resultsmentioning

confidence: 99%

Asbestos Fibers and Ferruginous Bodies Detected by VP-SEM/EDS in Colon Tissues of a Patient Affected by Colon-Rectum Cancer: A Case Study

Rinaudo

Croce

Erra³

et al. 2021

Minerals

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The aim of this work was to inspect the presence of asbestos fibers in colon tissue from a patient, with history of indirect exposure to asbestos and affected by colon cancer, who underwent surgery. Variable pressure scanning electron microscopy, coupled with energy dispersive spectroscopy (VP-SEM/EDS), was used for identification of inorganic fibers and for their morphological- chemical characterization. Fresh tissue samples from both, healthy area close to the neoplasia and from the neoplastic regions, were separately digested to eliminate the biological matrix. The precipitate was analyzed by VP-SEM/EDS, identifying in samples from healthy tissue asbestos bodies and small asbestos fibers, and in samples from neoplastic tissue long fibers of asbestos, free from covering. A quantification of the asbestos bodies and the free fibers in the two type of specimens is proposed. Moreover, to locate the fibers in the biological medium, histological sections from the colon of the same patient were also examined. Free asbestos fibers appeared concentrated in the tissue bridge between the healthy and the neoplastic areas. Immuno-histochemical investigation performed on the neoplasia seems to exclude a role of microsatellite instability in the carcinogenesis process, suggesting an influence of the fibers.

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Section: Resultsmentioning

confidence: 99%

Asbestos Fibers and Ferruginous Bodies Detected by VP-SEM/EDS in Colon Tissues of a Patient Affected by Colon-Rectum Cancer: A Case Study

Rinaudo

Croce

Erra³

et al. 2021

Minerals

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Controlling the Number of Proteins with Dip‐Pen Nanolithography

et al. 2010

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Desired numbers of proteins can be positioned on surfaces by using dip‐pen nanolithography (DPN). Ferritin nanoarrays are fabricated by direct‐writing nanodroplets of a ferritin solution on TEM surfaces. After the contact‐angle value of these droplets is determined, the concentration of the inking protein solution and the diameter of the dot‐like feature can be modulated to position a single ferritin particle on a surface (see figure).

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Incorporation of Graphene Quantum Dots, Iron, and Doxorubicin in/on Ferritin Nanocages for Bimodal Imaging and Drug Delivery

Nasrollahi

Sana

Paramelle

et al. 2020

Advanced Therapeutics

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Graphene quantum dots (GQDs) have been emerging as next‐generation bioimaging agents because of their intrinsic strong fluorescence, photostability, aqueous stability, biocompatibility, and facile synthesis. In this work, GQDs are encapsulated in ferritin protein nanocages to develop multi‐functional nanoplatforms toward multi‐modal imaging and cancer therapy. Encapsulation of ultra‐small GQDs is expected to reduce their quick excretion from the body and increase their bioimaging efficiency. To expand the functionality of protein nanocages as multi‐modal imaging nanoprobes capable of both fluorescence and magnetic resonance imaging (MRI), GQDs and iron are encapsulated inside the core of AfFtn‐AA (an engineered ferritin nanocage derived from the archaeon Archaeoglobus fulgidus). The co‐encapsulation is achieved through an iron‐mediated, self‐assembly of ferritin dimers resulting in the formation of GQD–iron complex in the ferritin nanocages ((GQDs/Fe)AA). The (GQDs/Fe)AA shows high relaxivities in MRI and pH‐sensitive fluorescence with strong fluorescence at low pH values and on MDA‐MB‐231 cells. As an imaging agent and a drug nanocarrier, (GQDs/Fe)AA exhibits negligible cytotoxicity on the cells and a high loading capacity (35%) of doxorubicin. Taken together, the (GQDs/Fe)AA shows promising applications in cancer diagnosis and therapy as a pH‐responsive fluorophore, MRI agent, and drug nanocarrier.

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Crystal Structure of Ferrihydrite Nanoparticles Synthesized in Ferritin

Cited by 17 publications

References 17 publications

Asbestos Fibers and Ferruginous Bodies Detected by VP-SEM/EDS in Colon Tissues of a Patient Affected by Colon-Rectum Cancer: A Case Study

Asbestos Fibers and Ferruginous Bodies Detected by VP-SEM/EDS in Colon Tissues of a Patient Affected by Colon-Rectum Cancer: A Case Study

Controlling the Number of Proteins with Dip‐Pen Nanolithography

Incorporation of Graphene Quantum Dots, Iron, and Doxorubicin in/on Ferritin Nanocages for Bimodal Imaging and Drug Delivery

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