Crystal structure of dimethylbis(diisopropyldithiocarbamato-κ2
 S,S′)tin(IV), C16H34N2S4Sn

Haezam, Farah Natasha; Awang, Normah; Kamaludin, Nurul Farahana; Tiekink, Edward R. T.

doi:10.1515/ncrs-2019-0894

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“…Seven organotin(IV) dithiocarbamate compounds, which are diphenyltin(IV) diisopropyl dithiocarbamate (ODTC 1), diphenyltin(IV) diallyl dithiocarbamate (ODTC 2), triphenyltin(IV) diisopropyl dithiocarbamate (ODTC 3), triphenyltin(IV) diallyl dithiocarbamate (ODTC 4), triphenyltin(IV) diethyl dithiocarbamate (ODTC 5), dimethyltin(IV) diisopropyl dithiocarbamate (ODTC 6) and dimethyltin(IV) diethyl dithiocarbamate (ODTC 7) were synthesized and characterized by our team (Haezam et al) [22,47,48] at the School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Malaysia.…”

Section: Compoundsmentioning

confidence: 99%

Series of Organotin(IV) Compounds with Different Dithiocarbamate Ligands Induced Cytotoxicity, Apoptosis and Cell Cycle Arrest on Jurkat E6.1, T Acute Lymphoblastic Leukemia Cells

et al. 2023

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The discovery of cisplatin has influenced scientists to study the anticancer properties of other metal complexes. Organotin(IV) dithiocarbamate compounds are gaining attention as anticancer agents due to their potent cytotoxic properties on cancer cells. In this study, a series of organotin compounds were assessed for their toxic effects on the Jurkat E6.1 cell line. WST-1 assay was used to determine the cytotoxic effect of the compounds and showed that six out of seven organotin(IV) dithiocarbamate compounds exhibited potent cytotoxic effects toward T-lymphoblastic leukemia cells, Jurkat E6.1 with the concentration of IC50 ranging from 0.67–0.94 µM. The apoptosis assay by Annexin V-FITC/PI staining showed that all tested compounds induced cell death mainly via apoptosis. Cell cycle analysis assessed using RNase/PI staining showed that organotin(IV) dithiocarbamate compounds induced cell cycle arrest at different phases. In conclusion, the tested organotin(IV) dithiocarbamate compounds demonstrated potent cytotoxicity against Jurkat E6.1 cells via apoptosis and cell cycle arrest at low IC50 value. However, further studies on the mechanisms of action are required to probe the possible potential of these compounds on leukemia cells before they can be developed into anti-leukemic agents.

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Section: Compoundsmentioning

confidence: 99%

Series of Organotin(IV) Compounds with Different Dithiocarbamate Ligands Induced Cytotoxicity, Apoptosis and Cell Cycle Arrest on Jurkat E6.1, T Acute Lymphoblastic Leukemia Cells

et al. 2023

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Crystal structure of dimethylbis(diisopropyldithiocarbamato-κ² S,S′)tin(IV), C₁₆H₃₄N₂S₄Sn

Abstract: C16H34N2S4Sn, monoclinic, P21/n (no. 14), a = 10.6234(1) Å, b = 16.0898(1) Å, c = 13.2405(1) Å, β = 92.853(1)°, V = 2260.37(3) Å3, Z = 4, Rgt(F) = 0.0197, wRref(F2) = 0.0513, T = 100(2) K.

Cited by 1 publication

References 12 publications

Series of Organotin(IV) Compounds with Different Dithiocarbamate Ligands Induced Cytotoxicity, Apoptosis and Cell Cycle Arrest on Jurkat E6.1, T Acute Lymphoblastic Leukemia Cells

Series of Organotin(IV) Compounds with Different Dithiocarbamate Ligands Induced Cytotoxicity, Apoptosis and Cell Cycle Arrest on Jurkat E6.1, T Acute Lymphoblastic Leukemia Cells

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Crystal structure of dimethylbis(diisopropyldithiocarbamato-κ2 S,S′)tin(IV), C16H34N2S4Sn

Abstract: C16H34N2S4Sn, monoclinic, P21/n (no. 14), a = 10.6234(1) Å, b = 16.0898(1) Å, c = 13.2405(1) Å, β = 92.853(1)°, V = 2260.37(3) Å3, Z = 4, Rgt(F) = 0.0197, wRref(F2) = 0.0513, T = 100(2) K.

Cited by 1 publication

References 12 publications

Series of Organotin(IV) Compounds with Different Dithiocarbamate Ligands Induced Cytotoxicity, Apoptosis and Cell Cycle Arrest on Jurkat E6.1, T Acute Lymphoblastic Leukemia Cells

Series of Organotin(IV) Compounds with Different Dithiocarbamate Ligands Induced Cytotoxicity, Apoptosis and Cell Cycle Arrest on Jurkat E6.1, T Acute Lymphoblastic Leukemia Cells

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Crystal structure of dimethylbis(diisopropyldithiocarbamato-κ² S,S′)tin(IV), C₁₆H₃₄N₂S₄Sn