Crystal structure of carnidazole form II from synchrotron X‐ray powder diffraction: Structural comparison with form I, the hydrated form and the low energy conformations in vacuo

Co-crystallization experiments of thiocarbamides with bipyridine-type molecules

“…56 The remaining 14 molecules feature Z-conformations and varied association between molecules. 56,[67][68][69][70][71][72][73][74][75][76][77]…”

Solid-State Studies of the Triclinic (Z′ = 2) Antiprotozoal Drug Ternidazole

“…1) and its derivatives are known for their antiprotozoic and antibiotic properties, 2,3 and a number of crystal structures of these compounds has been solved. [4][5][6][7][8][9] Despite these studies, little is known about the thermodynamic properties that can be used for the characterization of the active pharmaceutical ingredients important not only from a regulatory point of view but also for drug development.…”

“…For carnidazole, two polymorphic anhydrous phases with different melting temperatures and enthalpies have been characterized. 5,8 This case of dimorphism was accompanied with conformational changes (with only one conformation per crystal structure), that is, a case of conformational polymorphism according to the definition proposed by Bernstein and Hagler. 10,11 For metronidazole with a shorter chain (R = CH 2 CH 2 OH), polymorphism or multiple conformations have, until now, not been observed.…”

Polymorphism and Solvatomorphism 2006

“…The crystal structure of carnidazole Form-II was determined using synchrotron X-ray powder diffraction, and critically compared with the structures of the known crystal forms. 59 A more detailed summary of the crystallographic data of this crystal form has also been published by this same group. 60 Schmidt has continued to investigate the polymorphism and solvatomorphism associated with drug substances used as local anesthetics.…”