2005
DOI: 10.1110/ps.041183305
|View full text |Cite
|
Sign up to set email alerts
|

Crystal structure of a novel polyisoprenoid‐binding protein from Thermus thermophilus HB8

Abstract: The isoprenoid quinones exist widely among prokaryotes and eukaryotes. They play essential roles in respiratory electron transport and in controlling oxidative stress and gene regulation. In the isoprenoid quinone biosynthetic pathway, polyprenyl pyrophosphates are used as isoprenoid side-chain precursors. Here we report the crystal structure of a novel polyprenyl pyrophosphate binding protein, TT1927b, from Thermus thermophilus HB8, complexed with its ligand. This protein belongs to the YceI-like family in th… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
46
0

Year Published

2010
2010
2018
2018

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 40 publications
(47 citation statements)
references
References 26 publications
1
46
0
Order By: Relevance
“…Alvin_1468 falls into the YceI-like family of proteins; however, there is no sequence homology to E. coli YceI, a periplasmic protein induced by high pH, and the only structurally characterized member of the family, TT1927b from Thermus thermophilus. The latter binds polyprenyl pyrophosphate and structurally resembles the lipocalin fold (59). Lipocalins bind a range of small hydrophobic molecules and have been reported to participate in transport of insoluble substrates in Eubacteria (60).…”
Section: Resultsmentioning
confidence: 99%
“…Alvin_1468 falls into the YceI-like family of proteins; however, there is no sequence homology to E. coli YceI, a periplasmic protein induced by high pH, and the only structurally characterized member of the family, TT1927b from Thermus thermophilus. The latter binds polyprenyl pyrophosphate and structurally resembles the lipocalin fold (59). Lipocalins bind a range of small hydrophobic molecules and have been reported to participate in transport of insoluble substrates in Eubacteria (60).…”
Section: Resultsmentioning
confidence: 99%
“…Since the formation of acetyl-coA requires energy that is provided by pyruvate decarboxylation, the former pathway may be advantageous if prey-derived (aceto)acetyl-coA is available. It is noteworthy that almost all free-living non-predators, that may be potential prey, but not (Handa et al, 2005) were significantly more abundant in the BALOs, where they are upregulated during growth (Lambert et al, 2010;Wang et al, 2011); also, in myxobacteria a new pathway that branches from 3-hydroxy-3-methylglutaryl-CoA forms isovaleryl coenzyme A and compounds derived thereof, which are essential for fruiting body formation (Lorenzen et al, 2009). These examples of differential enrichment for a metabolic pathway, as well as for a particular tRNA synthetase gene (see above) in phylogenetically unrelated bacterial species suggest that they have been independently selected for and that they may confer as yet unknown selective advantages.…”
Section: Discussionmentioning
confidence: 99%
“…In E. coli, YceI is induced by alkaline pH and salt stress (43,44) and is proposed to be a secreted protein. Recently, the crystal structure of a member of the YceI protein family, TT1927b (TTHA0802) from Thermus thermophilus HB8, has been solved (45). The structure consists of an extended, eightstranded, antiparallel ␤-barrel.…”
Section: Discussionmentioning
confidence: 99%