Crystal Structure of a Novel 1,2,4- Triazolo[4,3-a]Pyridine Compound with Antifungal Activity

Wang, Q.; Zhai, Zhi-Wen; Sun, Zheng; Yang, Ming‐Yan; Li, Han; Liu, X.-H.; Tan, Cheng‐Xia; Weng, Jian‐Quan

doi:10.1134/s0022476618060331

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…The analogous bond lengths and angles are almost equal in both compounds. In general, the average bond lengths and bond angles of these rings are within the normal ranges [22,[24][25][26][27][28][30][31][32][33][34][35][36][37]. The unit cells of both 1 and 2 contain four molecules (Z = 4), and the 1,2,4-triazolo[4,3a]pyridine ring system in both structures accomplish a planar structure in accordance with similar systems previously reported.…”

Section: Crystal Structure and Formation Of Hydrogen Bondsupporting

confidence: 83%

Efficient Synthesis and X-ray Structure of [1,2,4]Triazolo[4,3-a]pyridines via Oxidative Cyclization Using N-Chlorosuccinimide (NCS)

et al. 2021

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Triazolopyridines are a family of compounds that, owing to their biological activity, have many pharmaceutical applications. In this study, 3-(pyridine-4-yl)-[1,2,4]triazolo[4,3-a]pyridine and 6-bromo-3-(pyridine-4-yl)-[1,2,4]triazolo[4,3-a]pyridine were synthesized by using the chlorinated agent NCS for hydrazones under very mild conditions. The characterization of these compounds was achieved by 1H NMR, 13C NMR, FTIR, MS and X-ray diffraction. The compound 3-(pyridine-4-yl)-[1,2,4]triazolo[4,3-a]pyridine was crystallized in the monoclinic space group P 21/c with a = 15.1413(12), b = 6.9179(4), c = 13.0938(8) Å, β = 105.102(6)°, V = 1324.16(16)Å3, Z = 4, and R = 0.0337. Also compound 6-bromo-3-(pyridine-4-yl)-[1,2,4]triazolo[4,3-a]pyridine was crystallized in the monoclinic space group P 21/c with a = 14.3213(11), b = 6.9452(4) (4), c = 12.6860(8)Å, β = 100.265(6)°, V = 1241.62(14)Å3, Z = 4, and R = 0.0561.

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Section: Crystal Structure and Formation Of Hydrogen Bondsupporting

confidence: 83%

Efficient Synthesis and X-ray Structure of [1,2,4]Triazolo[4,3-a]pyridines via Oxidative Cyclization Using N-Chlorosuccinimide (NCS)

et al. 2021

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“…[10][11][12][13] The bond lengths of Zn-N are in the range 1.9776(18)-2.320(2) Å, which are also in the normal range and comparable with those documented previously. [14][15][16][17][18][19] The result of a bond valence calculation reveals that all zinc ions are in a +2 oxidation state [Zn(1): 2.037; Synthesis, structure, photoluminescent and semiconductor properties of, and theoretical calculations for, a novel zinc complex Fig. 1 ORTEP drawing of 1 with 40% thermal ellipsoids and hydrogen atoms being omitted for clarity.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Structure, Photoluminescent and Semiconductor Properties of, and Theoretical Calculations for, a Novel Zinc Complex

Chen

Huang

et al. 2017

Journal of Chemical Research

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A novel zinc complex [Zn3(2,2′-bi-1H-imidazole)2(1H-biimidazole)2(SO4)2] n has been synthesised through a solvothermal reaction and structurally characterised by single-crystal X-ray diffraction. It has a one-dimensional chain-like structure with both tetrahedral and square pyramidal zinc atoms. A three-dimensional supramolecular framework is constructed through hydrogen-bonding interactions. Photoluminescence shows that the complex displays an emission in the blue region of the light spectrum that time-dependent density functional theory calculations reveal can be attributed to ligand-to-ligand charge transfer. Solid-state diffuse reflectance measurements show the existence of a narrow optical band gap of 2.08 eV.

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Crystal Structure of a Novel 1,2,4- Triazolo[4,3-a]Pyridine Compound with Antifungal Activity

Cited by 2 publications

References 21 publications

Efficient Synthesis and X-ray Structure of [1,2,4]Triazolo[4,3-a]pyridines via Oxidative Cyclization Using N-Chlorosuccinimide (NCS)

Efficient Synthesis and X-ray Structure of [1,2,4]Triazolo[4,3-a]pyridines via Oxidative Cyclization Using N-Chlorosuccinimide (NCS)

Synthesis, Structure, Photoluminescent and Semiconductor Properties of, and Theoretical Calculations for, a Novel Zinc Complex

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