Crystal structure of a native chitinase from the fungal pathogenAspergillus fumigatusYJ-407 (afCHI)

Abstract

decreased flexibility provides a basis to explain the low affinity of ONC towards nucleotides and, more generally, its lower catalytic activity. The results also suggest the basis of the unusually high thermal stability of the enzyme.[1] [1] Merlino A., et al., J. Biol. Chem., accepted for publication.