2003
DOI: 10.1016/s0022-2836(02)01197-x
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Crystal Structure of a Hypoallergenic Isoform of the Major Birch Pollen Allergen Bet v 1 and its Likely Biological Function as a Plant Steroid Carrier

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Cited by 270 publications
(249 citation statements)
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“…NMR spectroscopy, together with molecular modelling, fluorescence spectroscopy, X-ray crystallography and MS, provided strong evidence that the cavity of both Pru av 1 and Bet v 1 interacts with steroids and other lipids [7][8][9], but their exact physiological function remains unclear. The P-loop is one of three highly conserved regions on the surface of the Bet v 1 molecule proposed as IgE epitopes leading to cross-reactivity with pollen allergens of other trees of the Fagales order [5].…”
Section: Introductionmentioning
confidence: 99%
“…NMR spectroscopy, together with molecular modelling, fluorescence spectroscopy, X-ray crystallography and MS, provided strong evidence that the cavity of both Pru av 1 and Bet v 1 interacts with steroids and other lipids [7][8][9], but their exact physiological function remains unclear. The P-loop is one of three highly conserved regions on the surface of the Bet v 1 molecule proposed as IgE epitopes leading to cross-reactivity with pollen allergens of other trees of the Fagales order [5].…”
Section: Introductionmentioning
confidence: 99%
“…This is revealed by the structures of a number of PR-10 proteins obtained by NMR and x-ray crystallography, such as Bet v 1 from birch (Betula spp. ; Gajhede et al, 1996;Markovic-Housley et al, 2003), four isoforms of LlPR10 from yellow lupin (Lupinus luteus; Biesiadka et al, 2002;Pasternak et al, 2005;Fernandes et al, 2008), VrCSBP (cytokininspecific binding protein) from mung bean (Vigna radiata; Pasternak et al, 2006), Pru av 1 from cherry (Prunus avium; Neudecker et al, 2001), and Ap g 1 from celery (Apium graveolens; Schirmer et al, 2005).…”
mentioning
confidence: 99%
“…The most rel evant termite-type allergens are the 7S and 11S globulins. 7S globulins include Arah1, Jugr2 and Sesi3, whereas the 11S globulins include the Arah3, soy glycinins, Bere2, Cora9 and Fage1 [32]. The third structure of the proteins belonging to the termite group consists of a series of antiparallel β leaves associated with an α-helix forming a cavity [32].…”
Section: Allergenic Vegetable Proteinsmentioning
confidence: 99%
“…7S globulins include Arah1, Jugr2 and Sesi3, whereas the 11S globulins include the Arah3, soy glycinins, Bere2, Cora9 and Fage1 [32]. The third structure of the proteins belonging to the termite group consists of a series of antiparallel β leaves associated with an α-helix forming a cavity [32]. This structure is also found in several lipocalin-like proteins involved in the transport of hydrophobic ligands, including milk β-lactoglobulin [32].…”
Section: Allergenic Vegetable Proteinsmentioning
confidence: 99%
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