“…The Cu(II) ion exhibits a Jahn–Teller-distorted octahedral geometry with tridentate κ 3 N,O,N′-coordination of the py 2 C(OH) 2 ligand. The axial Cu-O bond length (2.4429(1) Å) is longer than the equatorial distances Cu-N (2.0083(19)–2.0097(19) Å), which are comparable to previously reported copper complexes [ 28 , 29 ]. The crystal structure of 5 is stabilised by series of hydrogen bonds in the range of 2.787–3.5938 Å, mainly between the non-coordinated -OH groups of the gem -diol and the ClO 4 − ions ( Table S3 and Figure 5 b).…”
Section: Resultssupporting
confidence: 84%
“…According to the literature [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ], it appears that py 2 CO can exhibit different coordination modes in the presence of Cu(II) ions; it is most often found in the gem -diol form, as the neutral ligand py 2 C(OH) 2 , or, less frequently, as the anion py 2 CO(OH) − . It should be noted that the anionic form of the ligand favours the formation of multicore copper(II) complexes.…”
Section: Resultsmentioning
confidence: 99%
“…A similar phenomenon was observed for complexes with CH 3 COO − ions [ 32 , 34 , 37 ]. Additionally, copper complexes with gem -diol should be divided into (i) monomeric complexes with a distorted octahedral coordination centre [ 28 , 29 , 31 , 32 , 33 ] and (ii) dimeric complexes with a polyhedron in the form of a distorted square pyramid [ 30 , 38 ].…”
To evaluate the antioxidant activity of potential synthetic enzyme mimetics, we prepared new five copper(II) complexes via a self-assembly method and named them [Cu(2-(HOCH2)py)3](ClO4)2 (1), [Cu(2-(HOCH2)py)2(H2O)2]SiF6 (2), [Cu2(2-(HOCH2CH2)py)2(2-(OCH2CH2)py)2](ClO4)2 (3), [Cu(pyBIm)3](BF4)2·1.5H2O (4) and [Cu(py2C(OH)2)2](ClO4)2 (5). The synthetic protocol involved N,O- or N,N-donors: 2-(hydroxymethyl)pyridine (2-(HOCH2)py), 2-(hydroxyethyl)pyridine (2-(HOCH2CH2)py), 2-(2-pyridyl)benzimidazole (pyBIm), di(2-pyridyl)ketone (py2CO). The obtained Cu(II) complexes were fully characterised by elemental analysis, FTIR, EPR, UV-Vis, single-crystal X-ray diffraction and Hirshfeld surface analysis. Crystallographic and spectroscopic analyses confirmed chromophores of both monomeric ({CuN3O3} (1), {CuN2O4} (2), {CuN6} (4), {CuN4O2} (5)) and dimeric complex ({CuN2O3} (3)). Most of the obtained species possessed a distorted octahedral environment, except dimer 3, which consisted of two copper centres with square pyramidal geometries. The water-soluble compounds (1, 3 and 5) were selected for biological testing. The results of the study revealed that complex 1 in solutions displayed better radical scavenging activity than complexes 3, 5 and free ligands. Therefore, complex 1 has been selected for further studies to test its activity as an enzyme mimetic. The chosen compound was tested on the erythrocyte lysate of two groups of patients after undergoing chemotherapy and chemoradiotherapy. The effect of the tested compound (1) on enzyme activity levels (TAS, SOD and CAT) suggests that the selected complex can be treated as a functional mimetic of the enzymes.
“…The Cu(II) ion exhibits a Jahn–Teller-distorted octahedral geometry with tridentate κ 3 N,O,N′-coordination of the py 2 C(OH) 2 ligand. The axial Cu-O bond length (2.4429(1) Å) is longer than the equatorial distances Cu-N (2.0083(19)–2.0097(19) Å), which are comparable to previously reported copper complexes [ 28 , 29 ]. The crystal structure of 5 is stabilised by series of hydrogen bonds in the range of 2.787–3.5938 Å, mainly between the non-coordinated -OH groups of the gem -diol and the ClO 4 − ions ( Table S3 and Figure 5 b).…”
Section: Resultssupporting
confidence: 84%
“…According to the literature [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ], it appears that py 2 CO can exhibit different coordination modes in the presence of Cu(II) ions; it is most often found in the gem -diol form, as the neutral ligand py 2 C(OH) 2 , or, less frequently, as the anion py 2 CO(OH) − . It should be noted that the anionic form of the ligand favours the formation of multicore copper(II) complexes.…”
Section: Resultsmentioning
confidence: 99%
“…A similar phenomenon was observed for complexes with CH 3 COO − ions [ 32 , 34 , 37 ]. Additionally, copper complexes with gem -diol should be divided into (i) monomeric complexes with a distorted octahedral coordination centre [ 28 , 29 , 31 , 32 , 33 ] and (ii) dimeric complexes with a polyhedron in the form of a distorted square pyramid [ 30 , 38 ].…”
To evaluate the antioxidant activity of potential synthetic enzyme mimetics, we prepared new five copper(II) complexes via a self-assembly method and named them [Cu(2-(HOCH2)py)3](ClO4)2 (1), [Cu(2-(HOCH2)py)2(H2O)2]SiF6 (2), [Cu2(2-(HOCH2CH2)py)2(2-(OCH2CH2)py)2](ClO4)2 (3), [Cu(pyBIm)3](BF4)2·1.5H2O (4) and [Cu(py2C(OH)2)2](ClO4)2 (5). The synthetic protocol involved N,O- or N,N-donors: 2-(hydroxymethyl)pyridine (2-(HOCH2)py), 2-(hydroxyethyl)pyridine (2-(HOCH2CH2)py), 2-(2-pyridyl)benzimidazole (pyBIm), di(2-pyridyl)ketone (py2CO). The obtained Cu(II) complexes were fully characterised by elemental analysis, FTIR, EPR, UV-Vis, single-crystal X-ray diffraction and Hirshfeld surface analysis. Crystallographic and spectroscopic analyses confirmed chromophores of both monomeric ({CuN3O3} (1), {CuN2O4} (2), {CuN6} (4), {CuN4O2} (5)) and dimeric complex ({CuN2O3} (3)). Most of the obtained species possessed a distorted octahedral environment, except dimer 3, which consisted of two copper centres with square pyramidal geometries. The water-soluble compounds (1, 3 and 5) were selected for biological testing. The results of the study revealed that complex 1 in solutions displayed better radical scavenging activity than complexes 3, 5 and free ligands. Therefore, complex 1 has been selected for further studies to test its activity as an enzyme mimetic. The chosen compound was tested on the erythrocyte lysate of two groups of patients after undergoing chemotherapy and chemoradiotherapy. The effect of the tested compound (1) on enzyme activity levels (TAS, SOD and CAT) suggests that the selected complex can be treated as a functional mimetic of the enzymes.
“…Apart from the title complex, two others were isolated from the reaction mixture and structurally characterized. One was identical to that of Parker et al (2000), the other is reported in the following paper by Westcott et al (2008). For other related structures, see: Wang et al (1986); Mariezcurrena et al (1999).…”
Key indicators: single-crystal X-ray study; T = 100 K; mean (C-C) = 0.004 Å; R factor = 0.023; wR factor = 0.061; data-to-parameter ratio = 19.4.The title complex, [Cu 2 Br 3 (C 11 H 9 N 2 O 2 )] n , was one of three isolated by slow evaporation of an acetonitrile reaction mixture of CuBr 2 with di-2-pyridyl ketone (1:1 molar ratio). The title complex contains a 2:1 metal-to-ligand ratio of copper(II) with the hydrated form of the ligand, di-2-pyridylmethanediol. The two copper centers are bridged by a bromide ion and the alkoxy O atom, and the Cu-Cu distance is 2.9801 (5) Å . The dimeric units are further linked by bromide ions, leading to a two-dimensional extended bridged structure. O-HÁ Á ÁO hydrogen bonds are present in the crystal structure.
Related literatureApart from the title complex, two others were isolated from the reaction mixture and structurally characterized. One was identical to that of Parker et al.
“…One complex was reported previously by Parker et al (2000), the other is reported in the preceding paper by Zeller et al (2008). For other related structures, see : Wang et al (1986); Mariezcurrena et al (1999).…”
Key indicators: single-crystal X-ray study; T = 100 K; mean (C-C) = 0.009 Å; R factor = 0.065; wR factor = 0.199; data-to-parameter ratio = 40.6.The centrosymmetric title complex, [Cu 2 Br 4 (C 11 H 10 -N 2 O 2 ) 2 ]Á2H 2 O, was one of three complexes isolated by slow evaporation of an acetonitrile reaction mixture of CuBr 2 with di-2-pyridyl ketone (1:1 molar ratio). The title complex contains a 1:1 metal-to-ligand ratio of copper(II) with the hydrated form of the ligand di-2-pyridylmethanediol. The copper centers are bridged by bromide donors, leading to a Cu-Cu distance of 4.090 (6) Å . The crystals form as nonmerohedral twins with two components related by a 180 rotation around the normal to [100]; the selected sample had a twin ratio of 0.63:0.37.
Related literatureApart from the title complex, two others were isolated from the reaction mixture and structurally characterized. One complex was reported previously by Parker et al.
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