Crystal structure of a 2:1 co-crystal of meloxicam with acetylendicarboxylic acid

Abstract

The crystal structure of a new 2:1 co-crystal of meloxicam and acetyl­endi­carb­oxy­lic acid is reported

Intermolecular interaction as a direct measure of water solubility advantage of meloxicam cocrystalized with carboxylic acids

“…Meloxicam can form multicomponent solids, and the majority of them comprise carboxylic acids. This encompasses cocrystallization of meloxicam with the following monocarboxylic acids: benzoic acid [ 36 ], 4-hydroxybenzoic acid [ 36 ], aspirin [ 34 ], 2-hydroxybenzoic acid [ 35 , 36 ], 1-hydroxy-2 naphthoic acid [ 35 , 36 ], hydrocinnamic acid [ 36 ], glycolic acid [ 36 ]; and the following dicarboxylic acids: acetylendicarboxylic acid [ 46 ], succinic acid [ 35 , 37 , 47 ], glutaric acid [ 34 – 36 ], l -malic acid [ 34 – 36 ], fumaric acid [ 36 , 48 ], terephthalic acid [ 37 , 47 ] and hexanedioic acid [ 35 – 37 , 47 ]. The main structural motif observed in cocrystals is the supramolecular heterosynthon linking meloxicam moiety with –COOH group.…”

Co-crystallization of organic chromophore roseolumiflavin and effect on its optical characteristics

“…Roseolumiflavin-acetylenedicarboxylic acid (1 : 1) cocrystal (R : A). A is highly hygroscopic and tends to form a monohydrate, which does not participate in a cocrystallization, according to Tantardini et al 44 Thus, to synthesize the R : A co-crystal, an excess amount of A was used. A and R were mixed in a 2 : 1 molar ratio in a microcentrifuge tube with 15 μL acetonitrile and six milling balls.…”

Artemisinin–acetylenedicarboxylic acid cocrystal: screening, structure determination, and physicochemical property characterisation

“…Further investigations were conducted for the results of grinding 2 : 1 mixtures of ART and ACA, indicating that they were mixtures of ART and ART 2 -ACA cocrystals, where new peaks at 11.00°F into its monohydrate or amorphous form upon grinding, not participating in cocrystallisation. 24 Therefore, ART 2 -ACA cocrystals were formed from a 1 : 1 mixture of ART and ACA.…”

“…Although ACA has acute oral toxicity, 23 it could have potential for clinical use, for example, ACA can form cocrystals with meloxicam used in the treatment of rheumatoid arthritis. 24…”