Crystal structure of 3β,12α-dihydroxy-5β-cholan-24-oic acid (iso-deoxycholic acid)

Dexamethasone‐loaded β‐cyclodextrin for osteogenic induction of mesenchymal stem/progenitor cells and bone regeneration

“…For the DEX or AD‐DEX molecules that are associated with CD units by the inclusion interactions, the release of molecules occurs through dissociation of DEX or AD‐DEX from CD. Because of the high association constant between CD and AD 25‐27 in CD/AD‐DEX inclusion complex, a slow release rate was observed. Over the testing period of 144 hr, the release rate of AD‐DEX was found significantly slower than DEX from CD/DEX.…”

“…Particularly, the development of CD derivatives as drug delivery devices has strengthen their potential in enhancing loading of drugs, improving aqueous solubility of hydrophobic drugs, and modulating release rates of the incorporated drugs 22,23 . On the other hand, the unique inclusion architectures of CDs enables the engineering of host‐guest pairs, among which the inclusion complex of CD and adamantyl group (AD) has been widely investigated because of their high association constant 24‐26 . This interaction has been successfully applied to build supramolecular polymers 27‐29 and supramolecular assemblies 30‐32 between CD and AD‐containing molecules.…”

“…22,23 On the other hand, the unique inclusion architectures of CDs enables the engineering of host-guest pairs, among which the inclusion complex of CD and adamantyl group (AD) has been widely investigated because of their high association constant. [24][25][26] This interaction has been successfully applied to build supramolecular polymers [27][28][29] and supramolecular assemblies [30][31][32] between CD and AD-containing molecules.…”

Use of Bile Acids in Pharmacological and Supramolecular Applications

“…The effect of β‐orientation of the 3‐OH group on the formation of crystalline inclusion compounds has been studied by Vázquez Tato et al194 They observed that the crystals of iso‐deoxycholic acid, the 3β‐hydroxy epimer of deoxycholic acid, did not contain any guest molecules when recrystallised from p ‐xylene, thus clearly differing from the crystals of deoxycholic acid, which were recrystallised from o ‐, m ‐, and p ‐xylene with a host guest ratio of 2:1.…”

Crystal Structure of a Head-to-Head Bis(cholic)-Urea Dimer

“…However, the formation of hydrogen bonds by bile acids has been mainly studied in solid state, [14][15][16] and different patterns have been observed depending on the number, location and orientation of the hydroxy groups. [17][18] The effect of the length of the side chain has also been investigated. 19 On the other hand, N,N'-disubstituted ureas can act as both hydrogen-bond donors through their two NH protons, and acceptors through the lone pairs of the C=O group.…”