Crystal structure of (2E)-N-methyl-2-(2-oxo-1,2-dihydroacenaphthylen-1-ylidene)hydrazinecarbothioamide

Abstract

In the title compound, the acenapthylene ring system and the hydrazinecarbo­thio­amide unit (=N—NH—C=S—NH–) are essentially coplanar, making a dihedral angle of 1.59 (9)°. The mol­ecular conformation is stabilized by two weak intra­molecular hydrogen bonds (N—H⋯O and N—H⋯N), which generate S(6) and S(5) ring motifs.

Michael addition-driven synthesis of cytotoxic palladium(ii) complexes from chromone thiosemicarbazones: investigation of anticancer activity through in vitro and in vivo studies

“…In the crystal structure of complex 3 , a decrease in the CN bond length and an increase in the C–S and C–O bond lengths were noticed compared to the free chromone TSC ligand. 41 The bond lengths and angles around the central atom were in good agreement with similar Pd( ii )-TSC complexes. 42–44…”

“…In the crystal structure of complex 3, a decrease in the CQN bond length and an increase in the C-S and C-O bond lengths were noticed compared to the free chromone TSC ligand. 41 The bond lengths and angles around the central atom were in good agreement with similar Pd(II)-TSC complexes. [42][43][44] The spectroscopic and single crystal XRD results revealed the presence of OCH 3 at the C2 position of the chromone moiety of the TSC ligand of 3, which clearly indicated the occurrence of in situ Michael addition during the synthesis of Pd(II) complexes.…”

“…The success of any drug depends on the fact that it should act only on the affected region or cells while the normal cells remain unaffected. 41 H- and E-stained tissue slices of the organs (heart, liver, spleen, lung and kidney) were excised from the mice treated with control (saline), active Pd( ii ) complexes 2 and 3 (8 mg kg −1 for both) and cisplatin (4 mg kg −1 ). Optical microscopy examination of the liver, lung and kidney sections of the complexes treated mice exhibited normal histological architecture.…”

New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis studies

“…Condensation of thiosemicarbazide derivatives 2a-f with acenaphthalene-1,2-dione ( 1 ) in refluxing ethanol and in the presence of triethylamine (Et 3 N), gave the corresponding N -substituted-2-(2-oxoacenaphthylen-1(2 H )-ylidene)hydrazinecarbothioamide derivatives 3a-f 38 , 39 ( Scheme 1 ).…”