Crystal Structure of 2-(4-Hydroxy-3-Methoxyphenyl)-6- (4-Hydroxy-3-Methoxystyryl)-1-Methyl-2, 3-Dihydropyridine-4 (1H)-One by X-Ray Powder Diffraction

Abstract

Problem statement:The studied dihydropyridone was synthesized for the first time via the microwave assisted reaction of curcumin and methylamine and it is important to support the mechanism by the crystal structure. Approach: The crystal structure of the title compound was determined using high resolution x-ray diffraction. PowderSolve program was used to solve the structure while the refinement was done in material studio Reflex module. Results: The findings obtained with high-resolution x-ray powder diffraction and molecular location methods based on simulated annealing algorithm after Rietveld refinement showed that the monoclinic unit cell was a = 13.4925 Å, b = 12.8162 Å, c = 11.5231 Å, α = 90.000°, β = 99.0401°, γ = 90.000°; cell volume = 1967.85 Å 3 and space group P 21/a with 4 molecules in a unit cell. Conclusion/Recommendations: Powder diffractometry could be a powerful tool for determining crystal structures for organic molecules.

Microwave-Assisted Synthesis of Novel 2,3-Dihydro-4-Pyridinones

“…Dihydropyridones are important intermediates for the synthesis of natural products, particularly alkaloids, and have been investigated extensively as valuable building blocks for the construction of piperidines, perhydroquinolines, indolizidines, quinolizidines and other alkaloid ring systems possessing a wide range of biological and pharmacological properties [ 1 , 2 , 3 , 4 , 5 ]. For their synthesis, the addition of Grignard reagents to 1-acyl-4-methoxy pyridinium salts has been exploited by Commins [ 6 , 7 , 8 , 9 , 10 ].…”