Crystal Structure of 1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridyl)-3-quinoline Carboxylic Acid (Rosoxacin)

Abstract

Rosoxacin (1-ethyl-1,4-dihydro-4-oxo-7-(4-pyridyl)-3-quinoline carboxylic acid) is an antibiotic chemically and structurally related to nalidixic acid, because it contains a 4 quinolone nucleus (Fig. 1). This antibiotic is specific for gonococcal urethritis therapy, gonococcal

Advances in the synthesis of 4-aryl- and 4-hetarylpyridines

“…29 Thus, these compounds can be used in curing different neurodegenerative diseases. 30 Among 4-(het)arylpyridine derivatives, compounds with sedative and analgetic, 31 ± 33 antimicrobial, 34 antitumour and hypoglycemic action 35 ± 37 were revealed, while 4,4 H -bipyridyls exhibited pronounced herbicidal activity. 38 ± 40 To date, 4-(het)arylpyridines are less accessible compounds as compared with 2-(het)arylpyridines.…”

Crystal Structure of a Quinolone Antibiotic 8-Ethyl-5,8-dihydro-5-oxo-2-(1-pyrrolidinyl)pyrido[2,3-d]pyrimidine-6-carboxylic Acid

“…The ethyl group adopts a perpendicular position in relation to the nucleus of the molecule; the torsion angle (C(7)-N(8)-C(10)-C(11)) is 92.9(4)˚ and similar values are found in nalidixic acid 3 and in rosoxacin. 4 The pyrrolidinyl ring adopts a halfchair conformation and the torsion angle (N(3)-C(2)-N(12)-C(13)) is -1.4(3)˚. The dihedral angle between the least-squares planes, which define the molecule (pyridopyrimidine/pyrrolidinyl rings, pyridopyrimidine ring/carboxylic group and pyridopyrimidine ring/ethyl group) are 6.6(12), 1.1(8) and 87.5(5)˚, respectively.…”