Crystal structure of 1′-(2-methylpropyl)-2,3-dihydrospiro[1-benzothiopyran-4,4′-imidazolidine]-2′,5′-dione

Abstract

In the title compound, C 15 H 18 N 2 O 2 S, the 2,3-dihydro-1-benzothiopyran ring adopts a sofa conformation and the hydantoin ring is twisted with respect to the benzene ring at 78.73 (17) . In the crystal, pairs of N-HÁ Á ÁO hydrogen bonds link the molecules into inversion dimers.

Recent Advances in the Synthesis of Hydantoins: The State of the Art of a Valuable Scaffold

“…The most usual way to substitute the N -3 position of hydantoins is alkylation with halides in the presence of a base (usually potassium carbonate). This strategy was largely adopted for the preparation of 3-substituted hydantoin-containing compounds with potential biological activities. ,− Notably, 5,5-dimethylhydantoin derivatives were synthesized by this means for applications in antimicrobial polymer coatings, − as well as phenytoin derivatives. − …”