Crystal Structure and NQR of Two Copper (I) Complexes of 4,6-Dimethylpyrimidine-2-thione

Ramaprabhu, Sundara; Lücken, E. A. C.; Bérnardinelli, Gerald

doi:10.1515/zna-1994-1-229

Cited by 7 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The combination of the EXAFS data and the reduced Cu content of the H239A mutant Sco1 suggest that the single Cu(I) ion in Sco1 is coordinated by Cys-148, Cys-152, and His-239. Ample precedence exists for trigonal planar Cu(I) coordination with two thiolates and a nitrogen in small inorganic complexes (44,45).…”

Section: Discussionmentioning

confidence: 99%

Yeast Sco1, a Protein Essential for Cytochrome cOxidase Function Is a Cu(I)-binding Protein

Nittis

George

Winge

2001

Journal of Biological Chemistry

176

169

View full text Add to dashboard Cite

Sco1 is a conserved essential protein, which has been implicated in the delivery of copper to cytochrome c oxidase, the last enzyme of the electron transport chain. In this study, we show for the first time that the purified C-terminal domain of yeast Sco1 binds one Cu(I)/monomer. X-ray absorption spectroscopy suggests that the Cu(I) is ligated via three ligands, and we show that two cysteines, present in a conserved motif CXXXC, and a conserved histidine are involved in Cu(I) ligation. The mutation of any one of the conserved residues in Sco1 expressed in yeast abrogates the function of Sco1 resulting in a non-functional cytochrome c oxidase complex. Thus, the function of Sco1 correlates with Cu(I) binding. Data obtained from size-exclusion chromatography experiments with mitochondrial lysates suggest that fulllength Sco1 may be oligomeric in vivo.

show abstract

Section: Discussionmentioning

confidence: 99%

Yeast Sco1, a Protein Essential for Cytochrome cOxidase Function Is a Cu(I)-binding Protein

Nittis

George

Winge

2001

Journal of Biological Chemistry

176

169

View full text Add to dashboard Cite

show abstract

“…In this regard, we note that Chen and co-workers recently reported the synthesis of a copper(I) mercaptobenzoxazole cluster, [Cu(SR)] 6 (R = NOC 7 H 4 ), via a synthetic procedure similar to that reported for Cu 8 (MPP) 4 . Moreover, several copper mercaptopyrimidine complexes are known, and they often adopt oligomeric or polymeric structures. − We adopted a similar protonolysis protocol as was employed for [Cu(HMPP*)] 4 . Thus, reaction of 0.3 equiv of [Cu(NC t Bu 2 )] 4 with 1 equiv of HMPP, in THF, resulted in immediate deposition of [Cu(MPP)] n , which can be isolated in 94% yield as a pale yellow powder (eq ).…”

Section: Resultsmentioning

confidence: 99%

Subnanometer-Sized Copper Clusters: A Critical Re-evaluation of the Synthesis and Characterization of Cu₈(MPP)₄ (HMPP = 2-Mercapto-5-n-propylpyrimidine)

2017

View full text Add to dashboard Cite

We report a critical re-evaluation of the synthesis and characterization of Cu(MPP). This product was reportedly formed by the reaction of Cu(NO) with 2-mercapto-5-n-propylpyrimidine (HMPP) and NaBH, in ethanol, in the presence of [N(CH)][Br]. In our hands, we found no experimental evidence to support the existence of Cu(MPP) in the reaction mixture. Instead, we demonstrate that the material isolated from this reaction is a complex mixture containing [N(CH)], Br, NO, and 2-mercapto-5-n-propyl-1,6-dihydropyrimidine (HMPP*), along with the Cu(I) coordination polymer, [Cu(MPP)]. To support our conclusions, we have independently synthesized HMPP* and [Cu(MPP)], as well as the related Cu(I) coordination complexes, [Cu(HMPP*)] and [Cu(MPP*)]. All new materials were characterized by NMR spectroscopy and mass spectrometry, while HMPP*, [Cu(HMPP*)] (n = 4), and [Cu(MPP)] (n = 6) were also characterized by X-ray crystallography.

show abstract

“…Complexes that contain only Spym À and substituted derivatives in the coordination sphere of many transition metal ions were obtained as mononuclear structures. Hexanuclear complexes were obtained with Cu I and Ag I (Castro et al, 1992;Ramaprabhu et al, 1994;Kitagawa et al, 1992;Rodríguez et al, 2011;Li et al, 2013). Only a few compounds of p-block ions are known, i.e.…”

Section: Introductionmentioning

confidence: 99%

A three-dimensional metal–organic polymer: poly[bis(μ₂-pyrimidine-2-thiolato-κ⁴N¹,S:S,N³)lead(II)]

2015

View full text Add to dashboard Cite

The title compound, [Pb(C4H3N2S)2]n, was prepared by the reaction of [Pb(OAc)2]·3H2O (OAc is acetate) with pyrimidine-2-thione in the presence of triethylamine in methanol. In the crystal structure, the Pb(II) atom has an N4S4 coordination environment with four ligands coordinated by N- and S-donor atoms. This compound shows that the pyrimidine-2-thiolate anion can lead to a three-dimensional network when the coordination number of the metal ion can be higher than 6, as is the case with the Pb(II) ion. This compound presents only covalent bonds, showing that despite the possibility of the hemidirected geometries of Pb(II), the eight-coordinated ion does not allow the formation of an isolated molecular structure with pyrimidine-2-thiolate as the ligand.

show abstract

Crystal Structure and NQR of Two Copper (I) Complexes of 4,6-Dimethylpyrimidine-2-thione

Cited by 7 publications

References 13 publications

Yeast Sco1, a Protein Essential for Cytochrome cOxidase Function Is a Cu(I)-binding Protein

Yeast Sco1, a Protein Essential for Cytochrome cOxidase Function Is a Cu(I)-binding Protein

Subnanometer-Sized Copper Clusters: A Critical Re-evaluation of the Synthesis and Characterization of Cu₈(MPP)₄ (HMPP = 2-Mercapto-5-n-propylpyrimidine)

A three-dimensional metal–organic polymer: poly[bis(μ₂-pyrimidine-2-thiolato-κ⁴N¹,S:S,N³)lead(II)]

Contact Info

Product

Resources

About

Crystal Structure and NQR of Two Copper (I) Complexes of 4,6-Dimethylpyrimidine-2-thione

Cited by 7 publications

References 13 publications

Yeast Sco1, a Protein Essential for Cytochrome cOxidase Function Is a Cu(I)-binding Protein

Yeast Sco1, a Protein Essential for Cytochrome cOxidase Function Is a Cu(I)-binding Protein

Subnanometer-Sized Copper Clusters: A Critical Re-evaluation of the Synthesis and Characterization of Cu8(MPP)4 (HMPP = 2-Mercapto-5-n-propylpyrimidine)

A three-dimensional metal–organic polymer: poly[bis(μ2-pyrimidine-2-thiolato-κ4N1,S:S,N3)lead(II)]

Contact Info

Product

Resources

About

Subnanometer-Sized Copper Clusters: A Critical Re-evaluation of the Synthesis and Characterization of Cu₈(MPP)₄ (HMPP = 2-Mercapto-5-n-propylpyrimidine)

A three-dimensional metal–organic polymer: poly[bis(μ₂-pyrimidine-2-thiolato-κ⁴N¹,S:S,N³)lead(II)]