“…A search of the Cambridge Structural Database (CSD, v5.40, last update May 2019;Groom et al, 2016) for the (Z)-4-(thiophen-2-ylmethylidene)isoxazol-5(4H)-one unit gave five hits: 4-(2-hydroxybenzylidene)-3-methylisoxazol-5(4H)-one (AJESAK; Cheng et al, 2009), 2-(naphthalen-1-yl)-4-(thiophen-2-ylmethylidene)-1,3-oxazol-5(4H)-one (ERIXIN; Gü ndog du et al, 2011), (Z)-4-benzylidene-3-methylisoxazol-5(4H)-one (MBYIOZ01; Chandra et al, 2012), 2-methyl-4-(thiophen-2-ylmethylidene)-1,3-oxazol-5(4H)-one (WOYPIL; Sharma et al, 2015) and (Z)-4-(4-hydroxybenzylidene)-3methylisoxazol-5(4H)-one (VIDSAF; Zemamouche et al, 2018).…”