Crystal structure and cytotoxic activity of Cu(ii) complexes with bis-benzoxazolylhydrazone of 2,6-diacetylpyridine

Abstract

Based on bis-hetarylhydrazone H2L, a condensation product of 2,6-diacetylpyridine with 2-hydrazinobenzoxazole, a series of mononuclear copper(II) coordination compounds have been synthesized: [Cu(HL)NO3], [Cu(HL)(H2O)]ClO4, [Cu(HL)X] (X = Br−, X = Cl−)....

Copper(ii) coordination compounds based on bis-hydrazones of 2,6-diacetylpyridine: synthesis, structure, and cytotoxic activity

“…The comparison of the cytotoxic properties of complexes 2-6 with those of previously obtained copper(II) metal chelates 7-10 (Scheme 2 and Table 6) containing benzoxazole and quinoline fragments 23,24 showed that the most active CuCl 2 -based complexes are compounds with condensed six-membered rings ( phthalazine and quinoline).…”

“…17,20 Previously, in our work, a systematic series of copper complexes based on bis-quinolyl-and benzoxazolylhydrazones of 2,6-diacetylpyridine were studied. 23,24 An in vitro study of the cytotoxic properties of the compounds on the cancer cell lines Hep2 and HepG2 showed that all copper complexes exhibit cytotoxic activity several times greater than the activity of cisplatin and carboplatin. It was found that the activity is largely determined by the nature of the heterocyclic fragment, the acido ligand and the geometry of the coordination polyhedron.…”

Dinuclear Molybdenum(VI) Complexes Based on Flexible Succinyl and Adipoyl Dihydrazones

“…This flexibility is attributed to the hydrazone's nitrogen and oxygen atoms, which can engage in both chelating and bridging modes in metal-organic frameworks (MOFs) [3]. Such features make them suitable for the development of metal-organic assemblies for specialized applications related to, e.g., magnetism, catalysis [4], or biomedicine [5][6][7][8]. Furthermore, the prospect of E/Z isomerization, particularly as a response to different stimuli, such as light, pH, or heat, renders these systems suitable for the design of molecular switches or even more complex stimuli-responsive metal-organic architectures [9,10].…”