Crystal structure and antibacterial activity of scandenone (warangalone) from Erythrina plants

Peleyeju, Grace Busayo; Talla, Emmanuel; Tata, Charlotte Mungho; Fotsing, Marthe Carine Djuidje; Niemann, Nicolette; Rhyman, Lydia; Arderne, Charmaine; Ndinteh, Derek Tantoh; Ramasami, Ponnadurai

doi:10.1016/j.molstruc.2019.04.070

Cited by 7 publications

(8 citation statements)

References 45 publications

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“…Schneid 0.5–8 μg/mL against Gram-positive bacteria, 2 μg/mL E . coli, < 1 μg/mL against M. smegmatis [ 69 , 70 ] 4 Mammea B/BA Mammea americana L. 0.5–1 μg/mL against methicillin-sensitive and methicillin-resistant S. aureus strains [ 74 , 77 ] 5 Cannabinoids (e.g., cannabidiol, cannabigerol) Cannabis sativa L. 1–4 μg/mL against MRSA , multi-drug resistant Streptococcus pneumoniae, Enterococcus faecalis , and Clostridioides difficile [ 85 , 86 ] 6 27- epi -Scutianine N Scutia buxifolia Reissek 1.56 μg/mL against Enterobater aerogenes [ 126 ] 7 Berberine Hydrastis canadensis. L , Coptis chinensis Franch.…”

Section: Plants As Potential Source Of New Antibacterial Agentsmentioning

confidence: 99%

“…(Fabaceae) [ 69 ]. Over the years, this compound has been isolated from other members of Fabaceae especially the Erythrina species [ 70 ]. The compound has also been isolated from Maclura pomifera (Raf.)…”

Section: Plants As Potential Source Of New Antibacterial Agentsmentioning

confidence: 99%

“…It is however not as potent against Pseudomonas aeruginosa as it only shows a poor MIC of 32 μg/mL. Nkengfack et al (1997) reported MIC of 12.5 μg/mLof scandenone against Mycobacterium smegmatis , however, the MIC was recently reported to be < 1 μg/mL by Peleyeju et al (2019) [ 70 , 72 ]. In addition to testing the activity of the compound against M. smegmatis , the compound was tested against several Gram-negative and Gram-positive bacteria strains and generally reported a higher MICs of 12–64 μg/mL compared to previous reports [ 70 , 73 ].…”

Section: Plants As Potential Source Of New Antibacterial Agentsmentioning

confidence: 99%

See 2 more Smart Citations

Plant antibacterials: The challenges and opportunities

Berida,

Adekunle,

Dada-Adegbola

et al. 2024

Heliyon

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Section: Plants As Potential Source Of New Antibacterial Agentsmentioning

confidence: 99%

Section: Plants As Potential Source Of New Antibacterial Agentsmentioning

confidence: 99%

Section: Plants As Potential Source Of New Antibacterial Agentsmentioning

confidence: 99%

See 1 more Smart Citation

Plant antibacterials: The challenges and opportunities

Berida,

Adekunle,

Dada-Adegbola

et al. 2024

Heliyon

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“…The occurrence of (16) is frequently observed in the Erythrina species and other plant genera. The compound has been reported to possess pronounced antimicrobial, antinociceptive, antiinflammatory, antineoplastic, and anticancer properties, [21][22][23][24][25] among others. Scandenone was found to constitute 13% and 10%, respectively, of the most active fractions (Figure S2) of an ongoing bioguided isolation from the methanol extract.…”

Section: Bioactive Constituents Of C Platypetalum Extractsmentioning

confidence: 99%

Untargeted GC–MS metabolomics to identify and classify bioactive compounds in Combretum platypetalum subsp. oatesii (Rolfe) Exell (Combretaceae)

Umoh

Bojase

Masesane

et al. 2022

Phytochemical Analysis

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Introduction: Combretum platypetalum is used in traditional African healing practices against different infections. Unfortunately, no scientific knowledge of its phytochemical composition exists, except for the isolation of two compounds from the leaves.Scientific study has been limited to the leaves only, despite the applications of stems and roots in traditional medicine practice and natural product drug discovery programs. Objective: Omics was applied to identify and classify different volatile and semivolatile bioactive compounds in the leaf, stem, and root parts of C. platypetalum. The thermal stability of the plant constituents at 60-65 C extraction temperature by Soxhlet and maceration at room temperature on the type, class, and concentration of compounds in the leaf was further investigated. Method: A GC-MS untargeted metabolomics approach, automated deconvolution by the Automated Mass Spectral Deconvolution and Identification System (AMDIS) for GC-MS data, preprocessing by Metab R, and multivariate statistical data analysis were employed in this study. Results: A total of 97 phytoconstituents, including 17 bioactive compounds belonging to the terpenoids, flavonoids, long-chain fatty acids, and other unclassified structural arrangements distributed across C. platypetalum, were identified for the first time. A correlation (r = 0.782; P = 0.000) between Soxhlet and maceration extraction methods relative to resolved chromatographic peak areas of metabolites was established. Conclusion: Findings corroborate the reported bio-investigation of its leaf extracts, its traditional uses, and previous findings from the Combretum genus. The results substantiate the possible applications of C. platypetalum in natural product drug discovery and provide a guide for future investigations.

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“…Emails: tyfwang@jnu.edu.cn, baiweibin@163.com; wyfmsm@163.com † hese three authors have contributed equally to this work Peer review under responsibility of the International Association of Dietetic Nutrition and Safety of diferent tumors, of which 78 types of lavonoids and xanthones are considered as potential antitumor drugs [22]. Among them, warangalone isolated and puriied from the fruits of Cudrania Tricuspidata is an isolavone compound with antitumor biological activities [23]. At the same time, our previous studies have found that warangalone has excellent antioxidant activity and a good inhibitory efect against breast cancer cells MDA-MB-231 and MCF-7.…”

Section: Introductionmentioning

confidence: 99%

Warangalone Induces Apoptosis in HeLa Cells via Mitochondria‐Mediated Endogenous Pathway

Yao

Wang

Cai

et al. 2021

eFood

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Cervical cancer as one of the major malignant tumors seriously threatens women's health. More than 270,000 women die of cervical cancer each year. Warangalone is an isoflavone compound isolated from Cudrania tricuspidata with excellent antitumor activity. In this research, we investigated the molecular mechanism of warangalone-induced apoptosis in HeLa cells. The results show that warangalone can selectively and effectively inhibit HeLa cells proliferation. Warangalone can effectively inhibit the invasion and migration of HeLa cells. Furthermore, warangalone was confirmed to activate p53 and mitogen-activated protein kinase (MAPK) family signaling pathways to cause apoptosis. In this case, the expression of the B-cell lymphoma-2 (Bcl-2) family is regulated, and caspase-3 is eventually cleaved, finally triggering the mitochondrial apoptosis. In conclusion, warangalone can induce HeLa cells apoptosis via a mitochondria-mediated endogenous pathway, which represented the potential therapeutic effect of warangalone on cervical cancer.

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Crystal structure and antibacterial activity of scandenone (warangalone) from Erythrina plants

Cited by 7 publications

References 45 publications

Plant antibacterials: The challenges and opportunities

Plant antibacterials: The challenges and opportunities

Untargeted GC–MS metabolomics to identify and classify bioactive compounds in Combretum platypetalum subsp. oatesii (Rolfe) Exell (Combretaceae)

Warangalone Induces Apoptosis in HeLa Cells via Mitochondria‐Mediated Endogenous Pathway

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