Crystal structure and anti-inflammatory activity of (3E,5E)-3-(2-fluorobenzylidene)-1-((4-fluorophenyl)sulfonyl)-5-(pyridin-3-ylmethylene)piperidin-4-one, C₂₄H₁₈F₂N₂O₃S

Abstract

C24H18F2N2O3S, monoclinic, P21/c (no. 14), a = 15.180(5) Å, b = 10.221(3) Å, c = 13.556(4) Å, β = 106.628(4)°, V = 2015.3(10) Å3, Z = 4, Rgt(F) = 0.0530, wRref(F2) = 0.1342, T = 173(2) K.

Crystal structure of (3E,5E)-3,5-bis-4-methoxy-3-(trifluoromethyl)benzylidene)-1-methylpiperidin-4-one, C24H21F6NO3

“…Therein, (3E, 5E)-3,5-bis(arylene)-4-piperidones (BAPs) was a very distinguished class because they could inhibit tumor growth by anti-inflammatory and inhibiting NF-κB dependent signaling pathways [11]. Some symmetric and dissymmetric BAPs had been designed and synthesized as anti-tumor and anti-inflammatory agents [12][13][14][15][16][17][18]. However, BAPs have rarely been developed as anti-neuroinflammatory drugs.…”