1980
DOI: 10.1038/287755a0
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Crystal structure analysis of a complete turn of B-DNA

Abstract: DNA is probably the most discussed and least observed of all biological macromolecules. Although its role in biology is a central one, with many examples such as operators and restriction sites where specific base sequences have control functions or interact with specific enzymes, the structures that DNA can adopt have been based until now only on sequence-averaged fibre diffraction patterns. Recent improvements in triester synthesis methods have made possible the preparation of sufficient homogeneous DNA of p… Show more

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Cited by 840 publications
(576 citation statements)
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“…PCNA forms an 86-kDa homotrimeric ring 2 that encircles the DNA and anchors binding partners, preventing them from falling off the genomic template. The ring has an inner diameter of B35 Å, much wider than the B24 Å diameter of a DNA duplex in the B-form 3 . Apart from DNAediting factors, PCNA also interacts with non-enzymatic proteins that regulate cell cycle control and survival 4,5 .…”
mentioning
confidence: 99%
“…PCNA forms an 86-kDa homotrimeric ring 2 that encircles the DNA and anchors binding partners, preventing them from falling off the genomic template. The ring has an inner diameter of B35 Å, much wider than the B24 Å diameter of a DNA duplex in the B-form 3 . Apart from DNAediting factors, PCNA also interacts with non-enzymatic proteins that regulate cell cycle control and survival 4,5 .…”
mentioning
confidence: 99%
“…A year later, the second structure 5 uncovered lefthanded DNA. It was only in 1980 that the right-handed double helix proposed in 1953 could be seen in atomic detail 6 .…”
Section: Dna Discoveries Through Crystallographymentioning
confidence: 98%
“…responding to an overall B-DNA structure, exhibits many local deviations from it [4,5]. Further, more direct evidence of a non-uniform backbone conformation of DNA has been obtained by 31P NMR spectroscopy [6] and there is also evidence for the possible coexistence of the A and B conformations along a synthetic nucleic acid duplex [7,8].…”
Section: (C-g-c-g-a-a-t-t-c-g-c-g) Which Although Cor-mentioning
confidence: 99%