Crystal Polymorphism of Methyl 2,3,4-tri-O-acetyl-1-O-(trichloroacetimidoyl)-α-d-glucopyranouronate

Hayes, John A.; Eccles, Kevin S.; Elcoate, Curtis J.; Daly, Carla A.; Lawrence, Simon E.; Moynihan, Humphrey A.

doi:10.1007/s10870-013-0397-y

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…The physicochemical characterization of commercial drugs is important for standardization and evaluation of purity, making it suitable for the study of preformulation [12], interactions with excipients [13], decomposition kinetics [14], polymorphism [15], etc. The use of evolved gas analysis (EGA) regarding the products derived from the thermal decomposition of the active ingredients is important because these products may appear as impurities in commercial drugs [16,17] which makes the use of coupled TG-EGA-MIR a valuable tool, and it is currently employed in the study of thermal degradation of different materials [18,19].…”

Section: Plakogiannis and Mccauleymentioning

confidence: 99%

Solid-state thermal and spectroscopic studies of the anti-inflammatory drug sulindac using UV–Vis, MIR, NIR, DSC, simultaneous TG–DSC, and the coupled techniques TG-EGA-MIR and DSC–optical microscopy

Guerra

Gálico

Holanda

et al. 2016

J Therm Anal Calorim

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Simultaneous thermogravimetry-differential scanning calorimetry (TG-DSC), differential scanning calorimetry-optical microscopy (DSC-optical microscopy), online coupled thermogravimetry-infrared spectroscopy evolved gas analyses (TG-EGA-MIR), and spectroscopic techniques were used to study the non-steroidal anti-inflammatory drug sulindac in polymorphic form II. The TG-DSC curves, which were performed with the aid of DSCoptical microscopy, provided information concerning the thermal stability and decomposition profiles of the compound. From the TG-EGA-MIR coupled technique, it was possible to identify formaldehyde as a volatile compound that was released during thermal decomposition. A complete spectroscopic characterization in the ultraviolet, visible, near-and middle-infrared regions was performed in order to understand the spectroscopic properties of sulindac form II.

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