Crystal Packing‐Guided Construction of Hetero‐Oligomeric Peptidic Ensembles as Synthetic 3‐in‐1 Transporters

Abstract

Strategies to generate heteromeric peptidic ensembles via as ocial self-sorting process are limited. Herein, we report ac rystal packing-inspired social self-sorting strategy broadly applicable to diverse types of H-bonded peptidic frameworks.Specifically,acrystal structure of H-bonded alkyl chain-appended monopeptides reveals an inter-chain separation distance of 4.8 dictated by the H-bonded amide groups, which is larger than 4.1 separation distance desired by the tightly packed straight alkylchains.This incompatibility results in loosely packed alkyl chains,prompting us to investigate and validate the feasibility of applying bulkyt ert-butyl groups, modified with an anion-binding group,t oa lternatively interpenetrate the straight alkyl chains,modified with acrownether group.S tructurally,t his social self-sorting approach generates highly stable hetero-oligomeric ensembles,h aving alternated anion-and cation-binding units vertically aligned to the same side.Functionally,these hetero-oligomeric ensembles promote transmembrane transport of cations,anions and more interestingly zwitterionic species such as amino acids.

Naphthalene Diimide‐Based Metallacage as an Artificial Ion Channel for Chloride Ion Transport

“…[ 8 ] The first artificial ion channel, based on cyclodextrin, was reported in 1982. [ 9 ] Since then, many artificial ion channels have emerged [ 10 ] ; they were constructed from supramolecular structures such as macrocyclic stacked channels, [ 11 ] nanotube‐based artificial channels, [ 12 ] and supramolecular cage‐based ion channels. [ 13 ]…”