Crystal nucleation of salicylic acid in organic solvents

Abstract

Nucleation of salicylic acid in different solvents becomes gradually more difficult in the order: chloroform, ethyl acetate, acetonitrile, acetone, methanol and acetic acid. By comparing the results of metastable zone width and induction time experiments new insights are obtained.

Crystal Growth of Salicylic Acid in Organic Solvents

“…Parameters C and D are determined by the properties of the crystal growth system similar to the parameters A and B respectively of the BCF model. In the present work, C is treated as temperature-dependent, while D is considered temperature-independent, again using equation (5). The solid-liquid interfacial energy in equation (8) appears in formulae describing the radius of the two-dimensional critical nuclei that forms on the surface and is the source of new growth steps.…”

Influence of solvent on crystal nucleation of risperidone

“…An experimental apparatus identical to that described by Mealey et al 17 was employed to simultaneously monitor 20 individual nucleation experiments. Solutions were transferred from bath A at 55 C to bath B held at a temperature where the solutions were supersaturated (T supersat ).…”

“…17,24 Here we have used the lognormal cumulative distribution function (LCDF) and the exponential-based function of Jiang and ter Horst. 17,24 Here we have used the lognormal cumulative distribution function (LCDF) and the exponential-based function of Jiang and ter Horst.…”

Crystal Nucleation of Tolbutamide in Solution: Relationship to Solvent, Solute Conformation, and Solution Structure

“…[15] Different solvents can cause solute molecules to assumev astly different conformations, with the result that dif-ferent solvents can nucleate different conformational polymorphs. [16] After statistically measuring the induction time in several organic solvents, [17] our group has recently shown that the rate of nucleationo fs alicylica cid, as mall inflexible organic molecule, is relatedt ot he strength with which the solvent binds the molecule in solution. [6] As trong positive correlation is shown between the interfacial energy calculated from induction times and several experimental and modelled variables describing solvent-solute bonding at SA'sc arboxyl group:t he carbonyl peak shift in the Raman spectrumf or the salicylic acid monomer,t he DFT-derived (1:1) binding energyt ot he carbonyl group, the calorimetrically-derived enthalpyo fs olvent-solutei nteraction, and the DFT-derived solvation energy.…”