Crystal forms of torasemide: new insights

Rollinger, Judith M.; Gstrein, E.; Burger, A.

doi:10.1016/s0939-6411(01)00206-5

Cited by 36 publications

(33 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fundamental importance of pharmaceutical solid polymorphism is based on the fact that different solid-state forms of the same chemical compound may have different chemical and physical properties, such as chemical reactivity, apparent solubility, dissolution rate, and mechanical properties [1][2][3][4]. Such differences in these properties have potential effects on the ability to process and manufacture drug products, as well as on drug product bioavailability and stability.…”

Section: Introductionmentioning

confidence: 99%

Polymorph control of sulfamerazine by ultrasonic irradiation

Kurotani¹,

Hirasawa²

2008

Journal of Crystal Growth

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Polymorph control of sulfamerazine by ultrasonic irradiation

Kurotani¹,

Hirasawa²

2008

Journal of Crystal Growth

View full text Add to dashboard Cite

“…The control of the crystallization process of polymorphs and solvated crystals is important in the pharmaceutical industry because this process affects the bioavailability, stability, solubility, and morphology of pharmaceutical products [1][2][3]. The crystallization process is influenced by various operational factors, such as additives [4,5], solvents [6][7][8], and interfaces [5,9].…”

Section: Introductionmentioning

confidence: 99%

Effect of solvent and molecular structure on the crystallization of polymorphs of BPT esters

Kitamura

Hayashi

Hara

2008

Journal of Crystal Growth

View full text Add to dashboard Cite

“…[1][2][3] The crystallization process of polymorphs and solvated crystals is composed of the competitive nucleation and growth of these crystals and the transformation process from a metastable form to a stable form. 3 As these elementary processes occur simultaneously, the crystallization process of polymorphs is generally complicated.…”

Section: Introductionmentioning

confidence: 99%

Effect of Temperature on Antisolvent Crystallization and Transformation Behaviors of Thiazole-Derivative Polymorphs

Kitamura

Hironaka

2006

Crystal Growth & Design

View full text Add to dashboard Cite

Crystallization of the thiazole-derivative (BPT) was performed by adding water, which is an antisolvent for the solute, to methanol solutions of BPT. BPT has three polymorphs (A, B, C) and two solvates (BH(hydrate) and D(methanolate)). The effect of temperature on the polymorphic crystallization and transformation behavior was investigated in relation to the effect of the addition rate of water and the initial concentration. In the crystallization at temperatures between 333 and 313 K, the stable C form did not crystallize. At 333 K, the metastable A and BH forms crystallized competitively. At low initial concentration and slow addition rate, the A form crystallized preferentially, though at a high initial concentration and high addition rate BH tended to crystallize. It was presumed that the nucleation process of the unsolvated A form is not controlled by the dissociation equilibrium of the BH and D forms but is controlled by the kinetic process. This nucleation behavior of polymorphs at 333 K is very different from that at 323 K, which was reported previously, i.e., at low initial concentration BH crystallized, and at higher concentration the D form crystallized with BH. Furthermore, after crystallization at 333 K transformation from the BH form to the A form was observed, and it was found that the transformation rate decreases with the addition rate and the initial concentration. Such tendency is similar to that observed at 323 K. Conversely, at 313 K, the D form tended to crystallize preferentially. At low concentration the BH form also appeared with the D form, and it transformed to the D form. With a decrease of the temperature to 313 K, the D form becomes much more stable than the A and BH forms. This may accelerate preferential crystallization of the D form at 313 K. l. IntroductionPolymorphs and solvated crystals are increasingly prevalent problems in pharmaceutical industries because they affect the bioavailability, stability, solubility, and morphology of the products. 1-3 The crystallization process of polymorphs and solvated crystals is composed of the competitive nucleation and growth of these crystals and the transformation process from a metastable form to a stable form. 3 As these elementary processes occur simultaneously, the crystallization process of polymorphs is generally complicated. This crystallization process is influenced by various operational factors of crystallizations, e.g., additives, 4,5 solvents, 6,7 and interfaces. 5,8 To perform a selective crystallization of polymorphs, the mechanism of each elementary process in the crystallization should be cleared in relation with the operational conditions and the key controlling factor for the selective crystallization should be known. 3 Investigation of this problem will also lead to clarification of the crystallization mechanism of polymorphs. From the point of view mentioned above, we investigated the influential factor in the crystallization of polymorphs in various systems. 3,9 In pharmaceutical industries antisolvents are frequently...

show abstract

Crystal forms of torasemide: new insights

Cited by 36 publications

References 7 publications

Polymorph control of sulfamerazine by ultrasonic irradiation

Polymorph control of sulfamerazine by ultrasonic irradiation

Effect of solvent and molecular structure on the crystallization of polymorphs of BPT esters

Effect of Temperature on Antisolvent Crystallization and Transformation Behaviors of Thiazole-Derivative Polymorphs

Contact Info

Product

Resources

About