Crystal-facet-dependent denitrosylation: modulation of NO release from<i>S</i>-nitrosothiols by Cu<sub>2</sub>O polymorphs

Ghosh, Satadal; Roy, Punarbasu; Prasad, S. M.; Mugesh, Govindasamy

doi:10.1039/c9sc01374a

Cited by 23 publications

(27 citation statements)

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“…Similar to the previously reported examples, the fast shuffling of oxidation states at the copper center might be responsible for release of nitric oxide from GSNO at physiological pH. 56 3.4. Cytotoxicity and Luminescence Property in Mammalian Cells.…”

Section: Resultssupporting

confidence: 82%

“…In cells, SOD is known to control the levels of NO by carrying out denitrosylation reactions. Also, copper based enzymes, complexes, and materials are known to catalyze the denitrosylation reaction. ,,− However, the release of NO from nitrosothiols such as S -nitrosoglutathione (GSNO) by copper ions is more stoichiometric than catalytic . Therefore, development of copper-based complexes and nanomaterials that can catalyze the release of NO from GSNO is important.…”

Section: Resultsmentioning

confidence: 99%

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Highly Stable Pyrimidine Based Luminescent Copper Nanoclusters with Superoxide Dismutase Mimetic and Nitric Oxide Releasing Activity

Singh

Raul

Poulose

et al. 2020

ACS Appl. Bio Mater.

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Copper nanoclusters (CuNCs) are emerging as an interesting class of materials for various biomedical applications. In this work, we have designed highly stable nucleobase-capped luminescent CuNCs and studied the effect of substituents on the cluster composition and photophysical properties. The NCs exhibit exceptional stability in ambient atmosphere and show significant variation in the emission properties with a change in position of substituents on the ligand, thiouracil. This study represents the first example of a nanocluster that functionally mimics the activity of a major antioxidant enzyme, superoxide dismutase (SOD). In addition to their enzyme-mimetic activity, the CuNCs evince controlled release of nitric oxide (NO), a key gaseous molecule of endothelial system from S-nitrosothiol, S-nitrosoglutathione (GSNO). Further, to a greater significance, these luminescent CuNCs are readily taken up by the mammalian cells and exhibit low toxicity. The superoxide dismutase and NO releasing activity of the fluorescent, biocompatible copper nanoclusters suggest their potential application in both therapeutics and bioimaging.

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Section: Resultssupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Highly Stable Pyrimidine Based Luminescent Copper Nanoclusters with Superoxide Dismutase Mimetic and Nitric Oxide Releasing Activity

Singh

Raul

Poulose

et al. 2020

ACS Appl. Bio Mater.

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“…permission. [66] Copyright 2019, The Royal Society of Chemistry. (measured using protein concentrations) in the presence of PVC films with various loading of copper (CuDTTCT) and iron (FeDTTCT) complexes.…”

Section: Discussionmentioning

confidence: 99%

“…2a). [66] Octahedra-shaped nanoparticles showed 2-5 fold higher catalytic activity towards all examined RSNOs (e.g. GSNO, Snitroso-N-acetylcysteine (SNAC), S-nitrosohomocysteine (HCysNO), and CysNO) compared to rhombic dodecahedra-and cube-like nanoparticles (Figure 2b and Figure 2c).…”

Section: Coppermentioning

confidence: 99%

Enzyme Mimics for the Catalytic Generation of Nitric Oxide from Endogenous Prodrugs

Yang

Zelikin

Chandrawati

2020

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The highly diverse biological roles of nitric oxide (NO) in both physiological and pathophysiological processes have prompted great interest in the use of NO as a therapeutic agent in various biomedical applications. NO can exert either protective or deleterious effects depending on its concentration and the location where it is delivered or generated. This double-edged attribute, together with the short half-life of NO in biological systems, poses a major challenge to the realization of the full therapeutic potential of this molecule. Controlled release strategies show an admirable degree of precision with regards to the spatiotemporal dosing of NO but are disadvantaged by the finite NO deliverable payload. In turn, enzyme-prodrug therapy techniques afford enhanced deliverable payload but are troubled by the inherent low stability of natural enzymes, as well as the requirement to control pharmacokinetics for the exogenous prodrugs. The past decade has seen the advent of a new paradigm in controlled delivery of NO, namely localized bioconversion of the endogenous prodrugs of NO, specifically by enzyme mimics. These early developments are presented, successes of this strategy are highlighted, and possible future work on this avenue of research is critically discussed.

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“…To date, in order to expand the potential biomedical application of NO donor materials and control release of NO from RSNOs, various nanomaterials such as Cu 2 O, [10] metal organic frameworks (MOFs), [9,11] polymer immobilized Cu(II)‐ligand complexes [12] and mesoporous silica [13] have been employed as storage and controlled release materials for NO. Among these materials, MOFs exhibited excellent performance due to the tunable physical and chemical properties, especially, the Cu‐based MOFs which have received extensive attention for catalyzing RSNOs due to the high activity and stability.…”

Section: Introductionmentioning

confidence: 99%

Understanding the Performance of Metal‐Organic Frameworks for Modulation of Nitric Oxide Release from S‐Nitrosothiols

Ling

Gao

Zang

et al. 2022

Chemistry An Asian Journal

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S-Nitrosothiols (RSNOs) which are important intermediates in circulating reservoirs of nitric oxide (NO), transport and numerous NO signaling pathways play intricate roles in the etiology of several pathologies. However, it is still a challenge to control the release of NO from nitrosylated compounds under physiological pH. In this paper, for the first time, we report the catalytic activity and kinetic study for the modulation of NO release from RSNOs by an array of metalorganic frameworks (MOFs) (M-MOF (M'); M=Zr, Cu; and M'=Cu, Pd, no metal) under physiological conditions via timedependent absorbance spectra. The result showed that metal active sites as well as the morphology and pore size of MOFs exhibited different activities toward RSNOs. The order of catalytic activity of these MOFs toward RSNOs is ordered in the decreasing sequence: Cu-MOF(Pd) > Cu-MOF(Cu) > Cu-MOF(no metal) > Zr-MOF(Pd) > Zr-MOF(Cu) > Zr-MOF(no metal). In addition, Zr-MOF(Pd) was as model for cell experiment, demonstrated Zr-MOF(Pd) could react with RSNOs to generate NO in the complex environment of cell. Collectively, these findings establish a platform for MOFs-based, highly catalyze RSNOs in biological samples, a powerful tool for expanding the knowledge of the biology and chemistry of NO-mediated phenomena.

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Crystal-facet-dependent denitrosylation: modulation of NO release fromS-nitrosothiols by Cu₂O polymorphs

Abstract: Crystal facet-dependent Cu2O-mediated denitrosylation of S-nitrosothiols and release of nitric oxide (NO) are described.

Cited by 23 publications

References 67 publications

Highly Stable Pyrimidine Based Luminescent Copper Nanoclusters with Superoxide Dismutase Mimetic and Nitric Oxide Releasing Activity

Highly Stable Pyrimidine Based Luminescent Copper Nanoclusters with Superoxide Dismutase Mimetic and Nitric Oxide Releasing Activity

Enzyme Mimics for the Catalytic Generation of Nitric Oxide from Endogenous Prodrugs

Understanding the Performance of Metal‐Organic Frameworks for Modulation of Nitric Oxide Release from S‐Nitrosothiols

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Crystal-facet-dependent denitrosylation: modulation of NO release fromS-nitrosothiols by Cu2O polymorphs

Abstract: Crystal facet-dependent Cu2O-mediated denitrosylation of S-nitrosothiols and release of nitric oxide (NO) are described.

Cited by 23 publications

References 67 publications

Highly Stable Pyrimidine Based Luminescent Copper Nanoclusters with Superoxide Dismutase Mimetic and Nitric Oxide Releasing Activity

Highly Stable Pyrimidine Based Luminescent Copper Nanoclusters with Superoxide Dismutase Mimetic and Nitric Oxide Releasing Activity

Enzyme Mimics for the Catalytic Generation of Nitric Oxide from Endogenous Prodrugs

Understanding the Performance of Metal‐Organic Frameworks for Modulation of Nitric Oxide Release from S‐Nitrosothiols

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Crystal-facet-dependent denitrosylation: modulation of NO release fromS-nitrosothiols by Cu₂O polymorphs