Crystal engineering of ferrocene-based charge-transfer complexes for NIR-II photothermal therapy and ferroptosis

Ge, Wei; Liu, Chao; Xu, Yatao; Zhang, Jiayao; Si, Weili; Wang, Wenjun; Ou, Changjin; Dong, Xiaochen

doi:10.1039/d2sc03273b

Cited by 8 publications

(3 citation statements)

References 29 publications

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“…In vivo experiments showed that the multifunctional F4TCNQ-based CTCs can effectively kill tumors under the combination of 1060 nm laser-triggered PTT and cell ferrotherapy. [16,56,101] Photothermal immunotherapy can effectively avoid the weakness of a single PTT and process a good inhibitory effect on distant tumors via immunotherapy, which has become a promising therapeutic strategy. F4TCNQ-based CTCs can combine with programmed cell death protein to suppress tumor immune evasion and improve NIR-II PTT.…”

Section: Anticancermentioning

confidence: 99%

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Organic Charge‐Transfer Complexes for Near‐Infrared‐Triggered Photothermal Materials

Zheng

et al. 2022

Small Structures

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When light-absorbing materials are excited by visible or near-infrared (NIR) light, they will eventually come back to their original equilibrium state, and a part of the absorbed photon energy is released as heat through nonradiative transitions during this process. The heat is determined by absorption ability under excitation wavelength and photothermal conversion efficiency, which is strongly related to the radiative and nonradiative transition rates. A good photothermal material should have high photothermal conversion efficiency, suitable absorption spectrum, and high light absorption ability, and can be used for photoacoustic imaging, [1][2][3] cancer photothermal therapy, [4,5] seawater desalination, [6][7][8] lightdriven thermoelectric system, [9,10] and so on. Especially, the second infrared window (NIR-II, 1000-1700 nm) absorbed photothermal materials have received much attention in biological applications for weak light scattering, low tissue absorption, deep tissue penetration depth, and high maximum permission exposure (up to 1.0 W cm À2 under 1064 nm laser excitation). Up to now, varied photothermal materials can roughly be categorized into two parts: inorganic materials and organic counterparts. For the potential long-term toxicity of inorganic materials, organic counterparts possess low toxicity, easy structural modification, tunable properties, and abundant molecules, so organic photothermal materials have rapidly developed during the last two decades. Typical organic photothermal materials embrace porphyrin, [11] cyanine dyes, [12,13] diketopyrrolopyrrole, [5] polyaniline, [14] polypyrrole, [15] semiconducting polymers, charge-transfer complexes (CTCs), [16] and so on.Among them, the CTCs are composed of electron-donating (D) and electron-accepting (A) molecules, and formed once charge delocalization takes place between the D and A leading to an enhanced molecular polarization, [17] which can be described as [18] In 1973, a famous CTC (TTF-TCNQ) was first reported, which was made of tetrathiafulvalene and 7,7 0 ,8,8 0 -tetracyanoquinodimethane; the researchers found that the electrical conductivity of TTF-TCNQ was comparable with metals. [19] From then on, the electrical properties of CTCs have got much attraction,

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Section: Anticancermentioning

confidence: 99%

“…In vivo experiments showed that the multifunctional F4TCNQ‐based CTCs can effectively kill tumors under the combination of 1060 nm laser‐triggered PTT and cell ferrotherapy. [ 16,56,101 ]…”

Section: Applications Of the Organic Photothermal Ctcsmentioning

confidence: 99%

Organic Charge‐Transfer Complexes for Near‐Infrared‐Triggered Photothermal Materials

Zheng

et al. 2022

Small Structures

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“…The efficient intermolecular charge transfer lowers the energy gap of CTCs and thus easily expands their absorptions beyond the second NIR region (NIR-II, > 1000 nm) for PTT. [59][60][61][62] Up to now, many OOMs have been directly used or modified for highperformance bioimaging and phototherapy which exhibit great potential for disease diagnosis and therapy. [63][64][65][66][67][68][69][70] Some excellent materials can even be used for imaging diagnosis and phototherapy simultaneously which is termed "phototheranostics".…”

Section: Introductionmentioning

confidence: 99%

Organic Optoelectronic Materials: A Rising Star of Bioimaging and Phototherapy

Lee,

Wan,

Huang

et al. 2023

Advanced Materials

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Recently, many organic optoelectronic materials (OOMs), especially those used in organic light‐emitting diodes (OLEDs), organic solar cells (OSCs), and organic field‐effect transistors (OFETs), are explored for biomedical applications including imaging and photoexcited therapies. In this review, we summarize recently developed OOMs for fluorescence imaging, photoacoustic imaging, photothermal therapy, and photodynamic therapy. Relationships between their molecular structures, nano‐aggregation structures, photophysical mechanisms, and properties for various biomedical applications are discussed. Mainly four kinds of OOMs are covered: thermally activated delayed fluorescence materials in OLEDs, conjugated small molecules and polymers in OSCs, and charge‐transfer complexes in OFETs. Based on the OOM's unique optical properties, including excitation light wavelength and exciton dynamics, they are respectively exploited for suitable biomedical applications. This review is intended to serve as a bridge between researchers in the area of organic optoelectronic devices and those in the area of biomedical applications. Moreover, it provides guidance for selecting or modifying OOMs for high‐performance biomedical uses. Current challenges and future perspectives of OOMs are also discussed with the hope of inspiring further development of OOMs for efficient biomedical applications.This article is protected by copyright. All rights reserved

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Ferrocene Derivatives for Photothermal Applications

Hu,

Fang,

Yao

et al. 2024

ChemSusChem

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Ferrocene (Fc) and Fc derivatives have gained popularity in recent years due to their unique structure and characteristics. Among Fc's diverse performances, photothermal conversion, as a primary source of energy conversion, has sparked substantial study attention. This review summaries Fc and Fc derivatives with photothermal characteristics, as well as their applications developed recently. First, methods for the synthesis of Fc‐based materials are systematically discussed. Then, the photothermal conversion mechanism based on nonradiative relaxation is summarized. Furthermore, the most recent advances in Fc‐based materials in photothermal applications are described, including photothermal degradation, photothermal antibacterial, photothermal therapies, photothermal catalysis, solar‐driven water production, and photothermal CO2 separation. Finally, a summary and insights on the photothermal application of Fc‐based materials are provided. This paper seeks to provide researchers with a better knowledge of photothermal behavior while also highlighting the potential of Fc and its derivatives in photothermal fields.

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Crystal engineering of ferrocene-based charge-transfer complexes for NIR-II photothermal therapy and ferroptosis

Abstract: Organic charge-transfer complexes (CTCs) can function as versatile second near-infrared (NIR-II) theranostic platforms to tackle complicated solid tumors, while the structure-property relationship is still an unanswered problem. To uncover the...

Cited by 8 publications

References 29 publications

Organic Charge‐Transfer Complexes for Near‐Infrared‐Triggered Photothermal Materials

Organic Charge‐Transfer Complexes for Near‐Infrared‐Triggered Photothermal Materials

Organic Optoelectronic Materials: A Rising Star of Bioimaging and Phototherapy

Ferrocene Derivatives for Photothermal Applications

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