Cryptotanshinone Alleviates Oxidative Stress and Reduces the Level of Abnormally Aggregated Protein in Caenorhabditis elegans AD Models

Cui, Wen-Bo; Zhang, Zongping; Bai, Xue; Wang, Shanshan; Chen, Xiaohan; Liu, Xu; Su, Pan-Jie; Zhi, Dejuan; Fei, Dong‐Qing; Zhang, Zhan‐Xin; Wang, Dongsheng

doi:10.3390/ijms231710030

Cited by 8 publications

(1 citation statement)

References 60 publications

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“…Moreover, supplementation with phloridzin reverses the inactivation of dopaminergic neurons observed in worm models of PD [94]. Other compounds, such as the natural product cryptotanshinone [95] or the glucagon-like peptide-1 receptor (GLP-1R) agonist Exendin-4 [96], have been tested in Caenorhabditis elegans models of AD, concluding that those drugs can decrease oxidative stress and protein aggregation and improve the disease phenotype. In the following paragraphs we will provide exam-ples of how oxidative stress is implicated in disease manifestations in three age-related neurodegenerative disorders, namely PD, AD and HD.…”

Section: Oxidative Stress In Ageing and Age-related Neurodegenerative...mentioning

confidence: 99%

Oxidative Stress in Age-Related Neurodegenerative Diseases: An Overview of Recent Tools and Findings

2023

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Reactive oxygen species (ROS) have been described to induce a broad range of redox-dependent signaling reactions in physiological conditions. Nevertheless, an excessive accumulation of ROS leads to oxidative stress, which was traditionally considered as detrimental for cells and organisms, due to the oxidative damage they cause to biomolecules. During ageing, elevated ROS levels result in the accumulation of damaged proteins, which may exhibit altered enzymatic function or physical properties (e.g., aggregation propensity). Emerging evidence also highlights the relationship between oxidative stress and age-related pathologies, such as protein misfolding-based neurodegenerative diseases (e.g., Parkinson’s (PD), Alzheimer’s (AD) and Huntington’s (HD) diseases). In this review we aim to introduce the role of oxidative stress in physiology and pathology and then focus on the state-of-the-art techniques available to detect and quantify ROS and oxidized proteins in live cells and in vivo, providing a guide to those aiming to characterize the role of oxidative stress in ageing and neurodegenerative diseases. Lastly, we discuss recently published data on the role of oxidative stress in neurological disorders.

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Section: Oxidative Stress In Ageing and Age-related Neurodegenerative...mentioning

confidence: 99%

Oxidative Stress in Age-Related Neurodegenerative Diseases: An Overview of Recent Tools and Findings

2023

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Cryptotanshinone‐Doped Photothermal Synergistic MXene@PDA Nanosheets with Antibacterial and Anti‐Inflammatory Properties for Wound Healing

Wei

Zhang

et al. 2023

Adv Healthcare Materials

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Humans are threatened by bacteria and other microorganisms, resulting in countless pathogen‐related infections and illnesses. Accumulation of reactive oxygen species (ROS) in infected wounds activates strong inflammatory responses. The overuse of antibiotics has led to increasing bacterial resistance. Therefore, effective ROS scavenging and bactericidal capacity are essential and the advanced development of collaborative therapeutic techniques to combat bacterial infections is needed. Here, this work developes an MXene@polydopamine‐cryptotanshinone (MXene@PDA‐CPT) antibacterial nanosystem with excellent reactive oxygen and nitrogen species scavenging ability, which effectively inactivates drug‐resistant bacteria and biofilms, thereby promoting wound healing. In this system, the adhesion of polydopamine nanoparticles to MXene produced a photothermal synergistic effect and free radical scavenging activity, presenting a promising antibacterial and anti‐inflammatory strategy. This nanosystem causes fatal damage to bacterial membranes. The loading of cryptotanshinone further expanded the advantages of the system, causing a stronger bacterial killing effect and inflammation mitigatory effect with desired biosafety and biocompatibility. In addition, combining nanomaterials and active ingredients of traditional Chinese medicine, this work provides a new rationale for the future development of wound dressings, which contributes to eliminating bacterial resistance, delaying disease deterioration, and alleviating the pain of patients.

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Ethyl caffeate attefnuates Aβ-induced toxicity in Caenorhabditis elegans AD models via the insulin/insulin-like growth factor-1 signaling pathway

Bai

Liu

et al. 2023

Bioorganic Chemistry

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Cryptotanshinone Alleviates Oxidative Stress and Reduces the Level of Abnormally Aggregated Protein in Caenorhabditis elegans AD Models

Cited by 8 publications

References 60 publications

Oxidative Stress in Age-Related Neurodegenerative Diseases: An Overview of Recent Tools and Findings

Oxidative Stress in Age-Related Neurodegenerative Diseases: An Overview of Recent Tools and Findings

Cryptotanshinone‐Doped Photothermal Synergistic MXene@PDA Nanosheets with Antibacterial and Anti‐Inflammatory Properties for Wound Healing

Ethyl caffeate attefnuates Aβ-induced toxicity in Caenorhabditis elegans AD models via the insulin/insulin-like growth factor-1 signaling pathway

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